Egypt assembly seeks to wrap up constitution

CAIRO (Reuters) - The assembly writing Egypt's constitution said it could wrap up a final draft later on Wednesday, a move the Muslim Brotherhood sees as a way out of a crisis over a decree by President Mohamed Mursi that protesters say gives him dictatorial powers.


But as Mursi's opponents staged a sixth day of protests in Tahrir Square, critics said the Islamist-dominated assembly's bid to finish the constitution quickly could make matters worse.


Two people have been killed and hundreds injured in countrywide protest set off by Mursi's decree.


The Brotherhood hopes to end the crisis by replacing Mursi's controversial decree with an entirely new constitution that would need to be approved in a popular referendum, a Brotherhood official told Reuters.


It is a gamble based on the Islamists' belief that they can mobilize enough voters to win the referendum: they have won all elections held since Hosni Mubarak was toppled from power.


But the move seemed likely to deepen divisions that are being exposed in the street.


The Muslim Brotherhood and its Islamist allies called for protests on Saturday in Tahrir Square, setting the stage for more confrontation with their opponents, who staged a mass rally there on Tuesday.


The constitution is one of the main reasons Mursi is at loggerheads with non-Islamist opponents. They are boycotting the 100-member constitutional assembly, saying the Islamists have tried to impose their vision for Egypt's future.


The assembly's legal legitimacy has been called into question by a series of court cases demanding its dissolution. Its popular legitimacy has been hit by the withdrawal of members including church representatives and liberals.


"We will start now and finish today, God willing," Hossam el-Gheriyani, the assembly speaker, said at the start of its latest session in Cairo, saying Thursday would be "a great day".


"If you are upset by the decree, nothing will stop it except a new constitution issued immediately," he said. Three other members of the assembly told Reuters there were plans to put the document to a vote on Thursday.


ENTRENCHING AUTHORITARIANISM


Just down the road from the meeting convened at the Shura Council, protesters were again clashing with riot police in Tahrir Square. Members of the assembly watched on television as they waited to go into session.


"The constitution is in its last phases and will be put to a referendum soon and God willing it will solve a lot of the problems in the street," said Talaat Marzouk, an assembly member from the Salafi Nour Party, as he watched the images.


But Wael Ghonim, a prominent activist whose online blogging helped ignite the anti-Mubarak uprising, said a constitution passed in such circumstances would "entrench authoritarianism".


The constitution is supposed to be the cornerstone of a new, democratic Egypt following Mubarak's three decades of autocratic rule. The assembly has been at work for six months. Mursi had extended its December 12 deadline by two months - extra time that Gheriyani said was not needed.


The constitution will determine the powers of the president and parliament and define the roles of the judiciary and a military establishment that had been at the heart of power for decades until Mubarak was toppled. It will also set out the role of Islamic law, or sharia.


The effort to conclude the text quickly marked an escalation, said Nathan Brown, a professor of political science at George Washington University in the United States.


"It may be regarded with hostility by a lot of state actors too, including the judiciary," he said.


Leading opposition and former Arab League chief figure Amr Moussa slammed the move. He walked out of the assembly earlier this month. "This is nonsensical and one of the steps that shouldn't be taken, given the background of anger and resentment to the current constitutional assembly," he told Reuters.


Once drafted, the constitution will go to Mursi for approval, and he must then put it to a referendum within 15 days, which could mean the vote would be held by mid-December.


COURTS DECLARE STRIKE


Deepening the crisis further on Wednesday, Egypt's Cassation and Appeals courts said they would suspend their work until the constitutional court rules on the decree.


The judiciary, largely unreformed since the popular uprising that unseated Mubarak, was seen as a major target in the decree issued last Thursday, which extended his powers and put his decisions temporarily beyond legal challenge.


"The president wants to create a new dictatorship," said 38-year-old Mohamed Sayyed Ahmed, an unemployed man, in Tahrir.


Showing the depth of distrust of Mursi in parts of the judiciary, a spokesman for the Supreme Constitutional Court, which earlier this year declared void the Islamist-led parliament, said it felt under attack by the president.


In a speech on Friday, Mursi praised the judiciary as a whole but referred to corrupt elements he aimed to weed out.


"The really sad thing that has pained the members of this court is when the president of the republic joined, in a painful surprise, the campaign of continuous attack on the Constitutional Court," said the spokesman Maher Samy.


Senior judges have been negotiating with Mursi about how to restrict his new powers.


Mursi's administration insists that his actions were aimed at breaking a political logjam to push Egypt more swiftly towards democracy, an assertion his opponents dismiss.


The West worries about turbulence in a nation that has a peace treaty with Israel and is now ruled by Islamists they long kept at arms length.


Trying to ease tensions with judges, Mursi said elements of his decree giving his decisions immunity applied only to matters of "sovereign" importance, a compromise suggested by the judges.


A constitution must be in place before a new parliament can be elected, and until that time Mursi holds both executive and legislative powers. An election could take place in early 2013.


(Additional reporting by Tom Perry and Marwa Awad; Writing by Edmund Blair and Tom Perry; Editing by Will Waterman and Giles Elgood)


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Only path to Palestinian state is direct talks: Clinton






WASHINGTON: US Secretary of State Hillary Clinton said on Wednesday that the only path towards a Palestinian state was through direct negotiations, on the eve of a contentious United Nations vote.

"I have said many times that the path to a two-state solution that fulfills the aspirations of the Palestinian people is through Jerusalem and Ramallah, not New York," Clinton told reporters, reiterating US opposition to the Palestinian bid to upgrade its UN status.

"We have made very clear to the Palestinian leadership that we oppose Palestinian efforts to upgrade their status at the UN outside of the framework" of direct negotiations.

The top US diplomat warned that no matter what happened on Thursday at the United Nations "it will not produce the outcome" that everyone desires.

"The only way to get a lasting solution is to commence direct negotiations," Clinton stressed.

"And we need an environment conducive to that and we urged both parties to refrain from actions that might, in any way, make a return to meaningful negotiations that focus on getting to a resolution more difficult."

The United States earlier on Wednesday pressed Palestinian president Mahmud Abbas not to seek elevated UN status, in a last-ditch bid to avert a damaging showdown at the United Nations.

US Deputy Secretary of State William Burns and Middle East envoy David Hale met with Abbas at his hotel but failed to get the Palestinian leader to withdraw his resolution or make amendments, officials said.

US officials have reaffirmed that the United States will vote against the Palestinian motion if the vote goes ahead as planned on Thursday.

- AFP/xq



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Indira Gandhi lent Indian politics the dynastic shift: Ramachandra Guha

BANGALORE: The Congress led by Indira Gandhi fostered a generation of hero worship and dynasty politics after 1969. This inspired many others like Muthuvel Karunanidhi, who started off with noble intentions to fight against caste discriminations, to do the same and has led to a centralization of politics in present India, said Ramachandra Guha, on Wednesday.

He was speaking during the launch of his latest book, Patriots and Partisans.

The 54-year-old historian went on to add that Jawaharlal Nehru, one of the most charismatic leaders of Indian politics, has been slowly losing his popularity because of the Congress's dynastic politics.

"Sins of seven successive generations have been bestowed on Nehru," he said light-heartedly.

The highest paid non-fiction writer of the country also slammed the phenomenon called the 'Congress chamchagiri'. "I saw a long queue of Congress party members waiting outside Rahul Gandhi's house during his birthday, a couple of years ago, braving scorching sun. Nevertheless, Rahul didn't come out to greet them while the 100 kilogram cake they had brought for him disintegrated leaving a trail from the Congress general secretary's house till the Indira Gandhi circle," he said.

He said that scientific institutions in Delhi couldn't achieve the success of ones in other parts of the country as officials chosen in the capital-based institutions are often selected on the recommendation of politicians.

Guha went on to add that massacre of Muslims in Hyderabad during the annexation of the state by the Indian army happened before the constitution came into being in 1950, but it is sad that the perpetrators of 1984 Sikh massacre and 2002 Muslim massacre in Gujarat, which were initiated by Congress and BJP, respectively, haven't still been punished.

He slammed right and left wing politicians, saying that the citizens have allowed the Hindu rightists' claims to be truly patriots of the country because the left is often considered anti-patriotic because their fatherland has always been a different country - depending upon the prevalence of Marxists movements in these countries, like China, the USSR, Cuba and currently Venezuela - and also due to the high decibel levels and angry outbreaks of the saffron brigade.

"Violence unleashed by left ( Naxalites) and right (Hindu fundamentalists) is against democracy, liberalism, religious plularism and tolerance, the idea that our Constitution promotes. Citizens should protect the country from these extremisms," he said.

TOO EARLY

Guha had a word of advice for the Arvind Kejriwal-launched Aam Aadmi Party, saying that it's too early for them to participate in the 2014 general elections. "Their current economic policies are a bit naive," he added.

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Simple measures cut infections caught in hospitals

CHICAGO (AP) — Preventing surgery-linked infections is a major concern for hospitals and it turns out some simple measures can make a big difference.

A project at seven big hospitals reduced infections after colorectal surgeries by nearly one-third. It prevented an estimated 135 infections, saving almost $4 million, the Joint Commission hospital regulating group and the American College of Surgeons announced Wednesday. The two groups directed the 2 1/2-year project.

Solutions included having patients shower with special germ-fighting soap before surgery, and having surgery teams change gowns, gloves and instruments during operations to prevent spreading germs picked up during the procedures.

Some hospitals used special wound-protecting devices on surgery openings to keep intestine germs from reaching the skin.

The average rate of infections linked with colorectal operations at the seven hospitals dropped from about 16 percent of patients during a 10-month phase when hospitals started adopting changes to almost 11 percent once all the changes had been made.

Hospital stays for patients who got infections dropped from an average of 15 days to 13 days, which helped cut costs.

"The improvements translate into safer patient care," said Dr. Mark Chassin, president of the Joint Commission. "Now it's our job to spread these effective interventions to all hospitals."

Almost 2 million health care-related infections occur each year nationwide; more than 90,000 of these are fatal.

Besides wanting to keep patients healthy, hospitals have a monetary incentive to prevent these infections. Medicare cuts payments to hospitals that have lots of certain health care-related infections, and those cuts are expected to increase under the new health care law.

The project involved surgeries for cancer and other colorectal problems. Infections linked with colorectal surgery are particularly common because intestinal tract bacteria are so abundant.

To succeed at reducing infection rates requires hospitals to commit to changing habits, "to really look in the mirror and identify these things," said Dr. Clifford Ko of the American College of Surgeons.

The hospitals involved were Cedars-Sinai Medical Center in Los Angeles; Cleveland Clinic in Ohio; Mayo Clinic-Rochester Methodist Hospital in Rochester, Minn.; North Shore-Long Island Jewish Health System in Great Neck, NY; Northwestern Memorial Hospital in Chicago; OSF Saint Francis Medical Center in Peoria, Ill.; and Stanford Hospital & Clinics in Palo Alto, Calif.

___

Online:

Joint Commission: http://www.jointcommission.org

American College of Surgeons: http://www.facs.org

___

AP Medical Writer Lindsey Tanner can be reached at http://www.twitter.com/LindseyTanner

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Petraeus Scandal: Socialite Jill Kelley Fighting Back













Tampa socialite Jill Kelley is fighting back. Today, sources close to the woman who was caught in the media crossfire during the David Petraeus sex scandal have released new letters aimed at reclaiming her reputation.


In one, Kelley's attorney goes after a New York businessman who claimed Kelley was using her connections to Petraeus to broker a deal with the South Korean government.


"It is impossible to overlook your attempt to get your '15 minutes of fame,'" attorney Abbe Lowell wrote to Adam Victor, the president and CEO of TransGas Development Systems. "…You have the right to do that to yourself, but you do not have the right to defame our client.


"This letter is notice to you that statements you have made are false and defamatory and are intended to portray Ms. Kelley in a false light," the letter continued.


Victor has claimed that Kelley asked for $80 million in commissions to arrange a deal between Victor and the South Korean government. Kelley was an honorary consul for the Republic of South Korean.


"While it is certainly true that Ms. Kelley communicated with you about a potential business deal, it has nothing to do with General Petraeus or other military," Lowell wrote Victor.








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The dealings between Jill Kelley and Adam Victor were detailed in a series of emails between the two made public earlier this month. The emails appeared to confirm the New York businessman's claim that Kelley wanted a huge fee for brokering a transaction with the South Korean government.


But in his letter to Victor, Lowell denies that Kelley wanted anything close to $80 million, and says the full chain of emails reveal that "it was you (Victor) who were trying to capitalize on her contacts, and not the other way around."


Kelley and Victor were introduced at the Republican National Convention in Tampa in August by Kelley's friend, Tampa real estate developer Don Phillips. In an interview with ABC News, Phillips said he suggested that Kelley and Victor should meet because Kelley could help Victor land a deal for a coal gasification plant in South Korea.


Phillips claimed that Kelley said that Victor tried to "proposition" her "almost immediately," and said he had to cajole her into flying to New York for a second meeting with Victor.


After she met with Victor in New York, Phillips said, Kelley reported that she was no longer interested in pursuing the deal. According to Phillips, she said, "As a result of my personal investigations and business intelligence this is just not going anywhere, Don, and you just don't want to associate with this guy."


Victor, who denies propositioning Kelley, claimed she continued pushing for the deal after their meeting in New York. But sources close to Kelley say that telephone voice messages Victor left for Kelley reveal that he was the one who continued to seek Kelley's involvement, even after the Petraeus affair came to light.


Victor also claims that Kelley told him Petraeus arranged for her to be named honorary consul, and that she could use her connections with high-level Korean officials to help land the coal plant deal.


None of the emails that Victor showed to ABC News mention Petraeus. Kelley's friend Don Phillips told ABC News that Kelley has not "in any way tried to profit" from her relationship with Petraeus.






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Egyptians challenge Mursi in nationwide protests

CAIRO (Reuters) - Tens of thousands of Egyptians rallied on Tuesday against President Mohamed Mursi in one of the biggest outpourings of protest since Hosni Mubarak's overthrow, accusing the Islamist leader of seeking to impose a new era of autocracy.


Police fired tear gas at stone-throwing youths in streets near the main protest in Cairo's Tahrir Square, heart of the uprising that toppled Mubarak last year. Clashes between Mursi's opponents and supporters erupted in a city north of Cairo.


But violence could not overshadow the show of strength by the normally divided opponents of Islamists in power, posing Mursi with the biggest challenge in his five months in office.


"The people want to bring down the regime," protesters in Tahrir chanted, echoing slogans used in the 2011 revolt.


Protesters also turned out in Alexandria, Suez, Minya and other Nile Delta cities.


Tuesday's unrest by leftists, liberals and other groups deepened the worst crisis since the Muslim Brotherhood politician was elected in June, and exposed the deep divide between the newly empowered Islamists and their opponents.


A 52-year-old protester died after inhaling tear gas in Cairo, the second death since Mursi last week issued a decree that expanded his powers and barred court challenges to his decisions.


Mursi's administration has defended the decree as an effort to speed up reforms and complete a democratic transformation in the Arab world's most populous country.


"Calls for civil disobedience and strikes will be dealt with strictly by law and there is no retreat from the decree," Refa'a Al-Tahtawy, Mursi's presidential chief of staff, told the Al-Hayat private satellite channel.


But opponents say Mursi is behaving like a modern-day pharaoh, a jibe once leveled at Mubarak. The United States, a benefactor to Egypt's military, has expressed concern about more turbulence in a country that has a peace treaty with Israel.


"We don't want a dictatorship again. The Mubarak regime was a dictatorship. We had a revolution to have justice and freedom," 32-year-old Ahmed Husseini said in Cairo.


The fractious ranks of Egypt's non-Islamist opposition have been united on the street by crisis, although they have yet to build an electoral machine to challenge the well-organized Islamists, who have beaten their more secular-minded rivals at the ballot box in two elections held since Mubarak was ousted.


MISCALCULATION


"There are signs that over the last couple of days that Mursi and the Brotherhood realized their mistake," said Elijah Zarwan, a fellow with The European Council on Foreign Relations. He said the protests were "a very clear illustration of how much of a political miscalculation this was".


Mursi's move provoked a rebellion by judges and has battered confidence in an economy struggling after two years of turmoil. The president still must implement unpopular measures to rein in Egypt's crushing budget deficit - action needed to finalize a deal for a $4.8 billion International Monetary Fund loan.


Some protesters have been camped out since Friday in Tahrir and violence has flared around the country, including in a town north of Cairo where a Muslim Brotherhood youth was killed in clashes on Sunday. Hundreds have been injured.


Supporters and opponents of Mursi threw stones at each other and some hurled petrol bombs in the Delta city of el-Mahalla el-Kubra. Medical sources said almost 200 people were injured.


"The main demand is to withdraw the constitutional declaration (decree). This is the point," said Amr Moussa, a former Arab League chief and presidential candidate who has joined the new opposition coalition, the National Salvation Front. The group includes several top liberal politicians.


Some scholars from the prestigious al-Azhar mosque and university joined Tuesday's protest, showing that Mursi and his Brotherhood have alienated some more moderate Muslims. Members of Egypt's large Christian minority also joined in.


Mursi formally quit the Brotherhood on taking office, saying he would be a president for all Egyptians, but he is still a member of its Freedom and Justice Party.


The decree issued on Thursday expanded his powers and protected his decisions from judicial review until the election of a new parliament, expected in the first half of 2013.


In Washington, White House spokesman Jay Carney urged demonstrators to behave peacefully.


"The current constitutional impasse is an internal Egyptian situation that can only be resolved by the Egyptian people, through peaceful democratic dialogue," he told reporters.


New York-based Human Rights Watch said the decree gives Mursi more power than the interim military junta from which he took over.


U.N. Secretary-General Ban Ki-moon told an Austrian paper he would encourage Mursi to resolve the issue by dialogue.


DECREE'S SCOPE DEBATABLE


Trying to ease tensions with judges, Mursi assured Egypt's highest judicial authority that elements of his decree giving his decisions immunity applied only to matters of "sovereign" importance. That should limit it to issues such as declaring war, but experts said there was room for interpretation.


In another step to avoid more confrontation, the Muslim Brotherhood cancelled plans for a rival mass rally in Cairo on Tuesday to support the decree. Violence has flared in Cairo in the past when both sides have taken to the streets.


But there has been no retreat on other elements of the decree, including a stipulation that the Islamist-dominated body writing a new constitution be protected from legal challenge.


"The decree must be cancelled and the constituent assembly should be reformed. All intellectuals have left it and now it is controlled by Islamists," said 50-year-old Noha Abol Fotouh.


With its popular legitimacy undermined by the withdrawal of most of its non-Islamist members, the assembly faces a series of court cases from plaintiffs who say it was formed illegally.


Mursi issued the decree on November 22, a day after he won U.S. and international praise for brokering an end to eight days of violence between Israel and Hamas around the Gaza Strip.


Mursi's decree was seen as targeting in part a legal establishment still largely unreformed from Mubarak's era, when the Brotherhood was outlawed.


Though both Islamists and their opponents broadly agree that the judiciary needs reform, Mursi's rivals oppose his methods.


Rulings from an array of courts this year have dealt a series of blows to the Brotherhood, leading to the dissolution of the first constitutional assembly and the lower house of parliament elected a year ago. The Brotherhood dominated both.


The judiciary blocked an attempt by Mursi to reconvene the Brotherhood-led parliament after his election victory. It also stood in the way of his attempt to sack the prosecutor general, another Mubarak holdover, in October.


In his decree, Mursi gave himself the power to sack that prosecutor and appoint a new one. In open defiance of Mursi, some judges are refusing to acknowledge that step.


(Additional reporting by Tom Perry, Seham Eloraby, Marwa Awad and Yasmine Saleh in Cairo and Michael Shields in Vienna; Writing by Edmund Blair and Tom Perry; Editing by Giles Elgood/Mark Heinrich)


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"Two and a Half Men cursed" says former star Sheen






LOS ANGELES: Perennially troubled US actor Charlie Sheen said Tuesday that hit TV series "Two and a Half Men," on which he starred for years, is "cursed," after one of its stars called the show "filth".

Sheen, who was sacked from the comedy show last year following his own public meltdown, was speaking as the show's producers remained tight-lipped about how they will deal with the outburst by actor Angus T. Jones.

"With Angus's Hale-Bopp-like meltdown, it is radically clear to me that the show is cursed," Sheen told celebrity bible People magazine, referring to the fiery comet.

Nineteen-year-old Jones, who reportedly earns $350,000 an episode playing the character Jake in the show now starring Ashton Kutcher, attacked the program after apparently undergoing a religious revelation.

"If you watch 'Two and a Half Men,' please stop watching 'Two and a Half Men.' I'm on 'Two and a Half Men,' and I don't want to be on it," he said in a video posted by the Forerunner Christian Church on YouTube.

"Please stop watching it; stop filling your head with filth. Please," he said in the video.

Jones signed up for a new one-year contract in May for the show -- from which Sheen was sacked after he gave a series of increasingly erratic and explosive interviews about the show's producer, Chuck Lorre.

Sheen -- who portrayed hedonistic jingle writer Charlie Harper -- was replaced by Kutcher on the top-rated comedy series, which has been a hit since it was launched in 2003.

The show's makers have so far declined to comment publicly on the young actor's outburst.

Paul McGuire, a spokesman for Warner Bros, which produces the show along with CBS, said on Monday: "We are not commenting on the comments made by Angus T. Jones."

- AFP/ck



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Mamata to decide on voting over FDI

KOLKATA: With the Congress likely to garner a majority in Parliament over the FDI issue, the Trinamool Congress is yet to carve out its strategy in Parliament, in case Lok Sabha Speaker Meira Kumar allows the debate under rule 184.

Trinamool leaders have left it to Trinamool chief Mamata Banerjee to decide whether the party will stage a walkout along with parties such as Samajwadi Party and Bahujan Samaj Party or record their dissent during voting with the BJP and the Left.

"We still believe that no-confidence motion is the only way to remove this minority government and stop this unethical political charade being played out. Even now this can be done.

Only one MP is required to move this motion. It doesn't matter which political party it is. Let those, who're so vocal on price rise, FDI in retail and removal of subsidy cap on domestic LPG, come forward and vote on it. If one is convinced that these are anti-people policies, what stops them from nudging the government out of power. Why resort to rules to save them?" said Trinamool all India general secretary Mukul Roy.

Roy was more keen on nailing down Left Front chairman Biman Bose's recent argument that the Left didn't support the Trinamool's no-confidence notice because parties reluctant to bring down the government would vote against the government if the debate is allowed under rule 184. Roy, however, didn't want to foretell the party's strategy in the fast changing situation.

While Trinamool Rajya Sabha MP Sukhendu Sekhar Ray held that the party will fight FDI tooth and nail, senior party MP Sultan Ahmed said, "Whether to vote or not will be decided later by the Trinamool parliamentary party and the party supremo Mamata Banerjee, let the Speaker decide it first. The government will never agree to a discussion under rule 184 without majority. Our leader in the Lok Sabha, Sudip Bandopadhyay, has already cleared our stand on the matter. There is nothing more to add to it." Domestic compulsion is also weighing heavily on Trinamool Congress before it is seen aligning with CPM and BJP.

Left parties, on the other hand, have dumped the number game getting a whiff that the Congress might gather the numbers. Asked whether the CPM is heading towards a situation similar to the confidence debate on the Indo-US civil nuclear deal, CPM Rajya Sabha MP Shyamal Chakrabarty said: "Not at all. We have been trying to forge the broadest possible unity against FDI entry in multi-brand retail. I am confident that we will be achieving our target to a great extent. The Trinamool's no confidence move would have given the government a leeway to continue with their anti-people policies on all fronts for a period of six months instead," Chakrabarty said.

Trinamool leaders, on the other hand, believe that a debate under rule 184, will give Trinamool an opportunity to expose the Opposition "double-speak." "Biman Bose had argued if the government survived our no-confidence motion, they will get a parliamentary mandate to introduce FDI in retail. So if a vote under rule 184 does take place and the government wins it, would it be any different? The CM had made it clear that we believed in moving a no-confidence for it wasn't a half-measure. What is happening now only vindicates her belief," a Trinamool MP said.

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CDC: HIV spread high in young gay males

NEW YORK (AP) — Health officials say 1 in 5 new HIV infections occur in a tiny segment of the population — young men who are gay or bisexual.

The government on Tuesday released new numbers that spotlight how the spread of the AIDS virus is heavily concentrated in young males who have sex with other males. Only about a quarter of new infections in the 13-to-24 age group are from injecting drugs or heterosexual sex.

The Centers for Disease Control and Prevention said blacks represented more than half of new infections in youths. The estimates are based on 2010 figures.

Overall, new U.S. HIV infections have held steady at around 50,000 annually. About 12,000 are in teens and young adults, and most youth with HIV haven't been tested.

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Online:

CDC report: http://www.cdc.gov/vitalsigns

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Rx OD Risks: Grapefruit-Meds Warning Expanded


Nov 26, 2012 5:48pm







gty grapefruit juice medication ll 121126 wblog Grapefruit, Medicine Interaction Warning Expanded

Image credit: Johner/Getty Images


ABC News’ Ben Maas reports:


It has long been known that grapefruit juice can pose dangerous — and even deadly — risks when taken along with certain medications. Now, experts warn the list of medications that can result in these interactions is longer than many may have believed.


Check below to see whether your medication appears on the list.


In a new report released Monday in the Canadian Medical Association Journal, researchers at the University of Western Ontario said that while 17 drugs were identified in 2008 as having the potential to cause serious problems when taken with grapefruit, this number has now grown to 43.


“The frequency of these reactions may be small, but the risks are not worth it, especially for drugs which could cause sudden death,” said lead study author David Bailey, a professor of pharmacology and one of the first to report the interactions between grapefruit juice and certain medications 20 years ago. “Physicians need to know that this affects a number of new drugs and apply this information to their practice and patients.”


So how does a common breakfast fruit cause these problems? Grapefruits contain chemicals called furanocoumarins that interfere with how your body breaks down drugs before they enter the bloodstream. By preventing this normal breakdown of a drug, these chemicals in grapefruit can effectively cause a drug overdose and more severe side-effects.


Among the side effects sometimes seen with grapefruit-induced overdoses are heart rhythm problems, kidney failure, muscle breakdown, difficulty with breathing and blood clots. Atorvastatin — commonly known by the brand name Lipitor and taken by millions of Americans — is one of the drugs that have been linked to serious cases of drug toxicity when combined with grapefruit products. Other common heart medications — including verapamil and amiodarone — have also led to serious interactions when consumed with grapefruit or grapefruit juice.


While there have been many reported cases of serious side effects attributable to this problem, the total number of Americans who have been affected is not known.


As little as one grapefruit or one 8-ounce glass of grapefruit juice can cause an effect that may last more than 24 hours.  Other fruits including Seville oranges, limes, and pomelos can have the same effect, although sweet orange varieties do not produce this interaction.



“People know that drugs react with drugs, but fewer are aware of drug-food interactions,” said Professor Paul Doering of the University of Florida Pharmacy Department. “Health professionals need to learn as much as they can about this.  Undetected there are very serious adverse effects.”


For consumers, the best advice may be to ask a doctor or pharmacist when they are prescribed a new drug whether there are foods or other medicines that they should avoid.



A-C
Alfentanil (oral)
Amiodarone
Apixaban
Atorvastatin
Buspirone
Clopidogrel
Crizotinib
Cyclosporine


D-F
Darifenacin
Dasatinib
Dextromethorphan
Domperidone
Dronedarone
Eplerenone
Erlotinib
Erythromycin
Everolimus
Felodipine
Fentanyl (oral)
Fesoterodine


H-P
Halofantrine
Ketamine (oral)
Latatinib
Lovastatin
Lurasidone
Maraviroc
Nifedipine
Nilotinib
Oxycodone


P-Z
Pazopanib
Pimozide
Primaquine
Quinine
Quetiapine
Quinidine
Rilpivirine
Rivaroxaban
Silodosin
Simvastatin
Sirolimus
Solifenacin
Sunitinib
Tacrolimus
Tamsulosin
Ticagrelor
Triazolam
Vandetanib
Venurafenib


Verapamil
Ziprasidone



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