Study could spur wider use of prenatal gene tests

A new study sets the stage for wider use of gene testing in early pregnancy. Scanning the genes of a fetus reveals far more about potential health risks than current prenatal testing does, say researchers who compared both methods in thousands of pregnancies nationwide.

A surprisingly high number — 6 percent — of certain fetuses declared normal by conventional testing were found to have genetic abnormalities by gene scans, the study found. The gene flaws can cause anything from minor defects such as a club foot to more serious ones such as mental retardation, heart problems and fatal diseases.

"This isn't done just so people can terminate pregnancies," because many choose to continue them even if a problem is found, said Dr. Ronald Wapner, reproductive genetics chief at Columbia University Medical Center in New York. "We're better able to give lots and lots of women more information about what's causing the problem and what the prognosis is and what special care their child might need."

He led the federally funded study, published in Thursday's New England Journal of Medicine.

A second study in the journal found that gene testing could reveal the cause of most stillbirths, many of which remain a mystery now. That gives key information to couples agonizing over whether to try again.

The prenatal study of 4,400 women has long been awaited in the field, and could make gene testing a standard of care in cases where initial screening with an ultrasound exam suggests a structural defect in how the baby is developing, said Dr. Susan Klugman, director of reproductive genetics at New York's Montefiore Medical Center, which enrolled 300 women into the study.

"We can never guarantee the perfect baby but if they want everything done, this is a test that can tell a lot more," she said.

Many pregnant women are offered screening with an ultrasound exam or a blood test that can flag some common abnormalities such as Down syndrome, but these are not conclusive.

The next step is diagnostic testing on cells from the fetus obtained through amniocentesis, which is like a needle biopsy through the belly, or chorionic villus sampling, which snips a bit of the placenta. Doctors look at the sample under a microscope for breaks or extra copies of chromosomes that cause a dozen or so abnormalities.

The new study compared this eyeball method to scanning with gene chips that can spot hundreds of abnormalities and far smaller defects than what can be seen with a microscope. This costs $1,200 to $1,800 versus $600 to $1,000 for the visual exam.

In the study, both methods were used on fetal samples from 4,400 women around the country. Half of the moms were at higher risk because they were over 35. One-fifth had screening tests suggesting Down syndrome. One-fourth had ultrasounds suggesting structural abnormalities. Others sought screening for other reasons.

"Some did it for anxiety — they just wanted more information about their child," Wapner said.

Of women whose ultrasounds showed a possible structural defect but whose fetuses were called normal by the visual chromosome exam, gene testing found problems in 6 percent — one out of 17.

"That's a lot. That's huge," Klugman said.

Gene tests also found abnormalities in nearly 2 percent of cases where the mom was older or ultrasounds suggested a problem other than a structural defect.

Dr. Lorraine Dugoff, a University of Pennsylvania high-risk pregnancy specialist, wrote in an editorial in the journal that gene testing should become the standard of care when a structural problem is suggested by ultrasound. But its value may be incremental in other cases and offset by the 1.5 percent of cases where a gene abnormality of unknown significance is found.

In those cases, "a lot of couples might not be happy that they ordered that test" because it can't give a clear answer, she said.

Ana Zeletz, a former pediatric nurse from Hoboken, N.J., had one of those results during the study. An ultrasound suggested possible Down syndrome; gene testing ruled that out but showed an abnormality that could indicate kidney problems — or nothing.

"They give you this list of all the things that could possibly be wrong," Zeletz said. Her daughter, Jillian, now 2, had some urinary and kidney abnormalities that seem to have resolved, and has low muscle tone that caused her to start walking later than usual.

"I am very glad about it," she said of the testing, because she knows to watch her daughter for possible complications like gout. Without the testing, "we wouldn't know anything, we wouldn't know to watch for things that might come up," she said.

The other study involved 532 stillbirths — deaths of a fetus in the womb before delivery. Gene testing revealed the cause in 87 percent of cases versus 70 percent of cases analyzed by the visual chromosome inspection method. It also gave more information on specific genetic abnormalities that couples could use to estimate the odds that future pregnancies would bring those risks.

The study was led by Dr. Uma Reddy of the National Institute of Child Health and Human Development.

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Medical journal: http://www.nejm.org

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Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP

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Tasting DNA-Altered Salmon That May Hit US Plates

Deep in the rain forests of Panama, in a secret location behind padlocked gates, barbed-wire fences and over a rickety wooden bridge, grows what could be the most debated food product of our time.

It may look like the 1993 hit movie "Jurassic Park," but at this real-life freshwater farm scientists are altering the genes not of dinosaurs -- but of fish.

They are growing a new DNA-altered saltwater fish in the mountains, far from the sea -- a salmon that could be the first genetically altered animal protein approved for the world to eat. If it is approved, this would be a landmark change for human food.

But it is one critics call "Frankenfish."

"The idea of changing an animal form, I think, is really creepy," said Gary Hirshberg, founder of Stonyfield Farm, an organic dairy farm. "When you move the DNA from a species into another species ... you create a new life form that's so new and so unique that you can get a patent for it."

And until now, AquaBounty, the multinational biotech company that for 20 years has been developing this giant fish, has kept it under close wraps.

The press has never been invited to its Prince Edward Island laboratory on the Canadian maritime coast, and its fish farm location in Panama has been kept secret out of fear of sabotage.

The Food and Drug Administration has seen it, but few from the outside. In fact, the last public tour of any kind was four years ago.

AquaBounty Creates 'Fort Knox for Fish'

ABC News was given exclusive access to see the facilities up close and an opportunity to taste this mysterious fish that FDA scientists say "is as safe as food from conventional Atlantic salmon," although have yet to officially approve it for public sale.

Ron Stotish, the president and CEO of AquaBounty Technologies, the company that created and hopes to market the eggs of this salmon to independent fish farms around the world, told ABC News it has employed bio-security measures, creating a "Fort Knox for fish," to ensure safety for the fish and prevent cross-contamination with the wild.

Entry to both facilities begins with body suits and iodine baths for shoes, which serves to keep the fish safe from germs.

Inside these protected tanks, America gets the first up-close look at the final product, the fish that has the food police up in arms.

"These are very healthy, beautiful Atlantic salmon," Stotish said.

With one big difference -- the growth rate of a regular salmon compared to that of an AquaBounty genetically modified fish.

While the AquaBounty fish do not grow to a size larger than normal salmon, they get to full size much faster, cutting costs for producers.

A normal-size 1-year-old Atlantic salmon averages 10 inches long, while the genetically modified fish at the same age is more than two times larger, coming in at 24 inches.

Salmon is the second most popular seafood in America. According to the National Oceanic and Atmospheric Administration, the average size of an Atlantic salmon is 28 inches to 30 inches and 8 pounds to 12 pounds after two years at sea.

How do they accomplish the accelerated growth?

"They differ by a single gene," Stotish said.

But, it's that single gene change that makes the DNA-altered salmon grow much faster than a normal Atlantic salmon, because it's really three fish in one.

AquaBounty scientists have taken a growth gene from the Chinook salmon and inserted it into the DNA of the Atlantic salmon because Chinooks grow fast from birth, while Atlantics do not.

"Salmon in their first two years of life grow very slowly," Stotish said.

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Britain braces for key budget update

LONDON: British finance minister George Osborne unveils his budget update on Wednesday, and will likely admit it could take longer than expected to slash the deficit as a result of the weaker-than-expected economy.

Chancellor of the Exchequer Osborne was to deliver his Autumn Statement before parliament at 1230 GMT, when the Office for Budget Responsibility (OBR) fiscal watchdog will also publish its latest growth and borrowing forecasts.

Osborne has already warned that economic recovery will take longer than hoped but insisted that abandoning the government's tough deficit-slashing austerity measures would be catastrophic amid the ongoing eurozone debt crisis.

"We had two targets, one was to get debt share falling as a share of national income by 2015/16 and also to balance the current budget," the chancellor told BBC television over the weekend.

"It's clearly taking longer to deal with Britain's debts; it's clearly taking longer to recover from the financial crisis than anyone would have hoped but we have made real progress."

Ahead of the budget update, Osborne pledged Tuesday to invest £5.0 billion in schools, transport and science over the next two fiscal years, with the cash sourced from a new raft of spending cuts across most civil service departments.

And on Monday, Osborne launched a campaign against "tax dodgers" and "cowboy advisers" to claw back £2.0 billion a year, as lawmakers alleged that multinationals such as Starbucks and Google are avoiding huge tax bills.

The OBR was meanwhile expected to lower its gross domestic product (GDP) forecasts as the economy faces major headwinds from state austerity, inflationary pressures and the eurozone's ongoing crisis.

Osborne had in March forecast that the British economy would grow by 0.8 per cent this year, followed by 2.0 per cent in 2013 and 2.7 per cent in 2014.

Weaker economic growth would slash taxation receipts and spark upward revisions to its official borrowing targets, according to analysts.

Alongside Osborne's budget in March, the OBR predicted that public sector net borrowing (PSNB) as a proportion of economic output would begin to fall in 2015/2016, after peaking at 76.3 per cent of GDP in 2014/15.

And it forecast state borrowing would reach £120 billion ($192 billion, 148 billion euros) in the 2012/2013 financial year ending in March, compared with £121.4 billion in 2011/2012.

But with PSNB already standing at £73.3 billion and four months of the financial year to go, Osborne could breach the target.

Recent official data showed Britain had escaped from recession in the third quarter of this year, with its economy growing 1.0 per cent.

However, experts argue this was due to one-off factors like the London Olympics and rebounding activity after public holidays in the second quarter.

The Conservative-Liberal Democrat coalition government imposed austerity measures to slash a record deficit inherited from the previous Labour administration. Opposition Labour politicians maintain that the cuts pushed the economy into a painful double-dip recession.

The Organisation for Economic Co-operation and Development urged Osborne last week to push back his debt reduction targets rather than drive through more growth-damaging austerity.

Meanwhile, the country's official statistics watchdog on Tuesday warned the government to stop claiming that real-terms National Health Service spending had increased after calculating funds had actually fallen slightly.

The UK Statistics Authority said Health Secretary Jeremy Hunt should "clarify" claims on the Conservative party website that "we have increased the NHS budget in real terms in each of the last two years".

- AFP/ck

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India urges Israel to speed up defence projects

NEW DELHI: India has asked Israel to speed up crucial bilateral defence projects, including the around Rs 13,000 crore development of two advanced surface-to-air missile (SAM) systems to arm Indian armed forces against hostile aircraft, drones and helicopters.

This came at the 10th joint working group on defence cooperation here, co-chaired by defence secretary Shashikant Sharma and Israeli defence ministry director-general Major-General Ehud Shani.

While the regional and global security situation, including the recent Israel-Hamas ceasefire, figured in the talks, the focus was on bilateral defence training programmes, exchanges, R&D projects and armament deals.

Israel is India's second largest defence supplier, second only to Russia, but the expansive ties are largely kept under wraps due to political sensitivities. Tel Aviv records military sales worth around $1 billion to New Delhi every year, ranging from Heron and Searcher UAVs, Harpy and Harop 'killer' drones to Barak anti-missile defence systems and Green Pine radars, Python and Derby air-to-air missiles.

Sources said India expressed "concern'' at the "two-year delay'' in completion of the long-range SAM (LR-SAM) project, sanctioned in December 2005 at a cost of Rs 2,606 crore to arm Indian warships.

There are "minor hitches'' even in the bigger Rs 10,076 crore medium-range SAM (MR-SAM) project, sanctioned in February 2009 for air defence squadrons of IAF.

Both the SAM systems, being developed by Israeli Aerospace Industries (IAI) in collaboration with DRDO, have the same missile with an interception range of 70-km. They are to be produced in bulk by defence PSU Bharat Dynamics (BDL) to plug the existing holes in India's air defence cover.

"While the multi-function surveillance and threat radars, weapon control systems with data links and the like of the LR-SAM have all been tested, there has been delay in the missiles being developed by IAI,'' said a source.

"But the Israelis said everything was sorted out now and they will try to make up for the delay. DRDO has already finished its work on the propulsion and other systems,'' he added. Incidentally, the LR-SAM project was to be completed by May this year.

Another major missile project, worth around $1 billion, that Israel could bag is the one to supply third-generation anti-tank guided missiles (ATGMs) to the 1.13-million strong Indian Army. The Army has already trial-evaluated the Israeli 'Spike' ATGM after the US offer of its 'Javelin' missiles was shelved due to Washington's reluctance to undertake "transfer of technology'' to ensure BDL can make them in large numbers, as reported by TOI earlier.

India is also in commercial negotiations for another two advanced Israeli Phalcon AWACS (airborne warning and control systems), capable of detecting hostile aircraft, cruise missiles and other incoming aerial threats far before ground-based radars, at a cost of over $800 million. The first three Phalcon AWACS were inducted by IAF in 2009-2010 under the $1.1 billion tripartite agreement between India, Israel and Russia.

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Study: Drug coverage to vary under health law

WASHINGTON (AP) — A new study says basic prescription drug coverage could vary dramatically from state to state under President Barack Obama's health care overhaul.

That's because states get to set benefits for private health plans that will be offered starting in 2014 through new insurance exchanges.

The study out Tuesday from the market analysis firm Avalere Health found that some states will require coverage of virtually all FDA-approved drugs, while others will only require coverage of about half of medications.

Consumers will still have access to essential medications, but some may not have as much choice.

Connecticut, Virginia and Arizona will be among the states with the most generous coverage, while California, Minnesota and North Carolina will be among states with the most limited.

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Avalere Health: http://tinyurl.com/d3b3hfv

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Suspect Allegedly Told Cops He Traveled to Kill

A man charged in the death of a teenage barista in Alaska told police that he traveled the country with the sole purpose to kill strangers because he "liked to do it," prosecutors said today.

Vermont and federal prosecutors detailed the meticulous and cold-blooded murder of Bill and Lorraine Currier in Essex, Vt., last year and said the information came from Israel Keyes before he killed himself in an Alaska jail cell Sunday. Keyes provided details that only the perpetrator would know, police said.

Keyes, 34, the owner of an Anchorage construction company, was in jail charged with the February murder of Samantha Koenig, 18. While in jail he had been confessing to at least seven other killings in Washington, New York and Vermont.

Now that he is dead, investigators are wondering how many more killings Keyes might be responsible for and why he committed the crimes.

"He provided some motivation, but I don't think it's really [possible] to pigeonhole why he did this," Tristram Coffin, U.S. Attorney in Vermont, said at a news conference today. "He described to investigators that this was a volitional act of his. He wasn't compelled by some uncontrollable force, but it was something that he could control and he liked to do it. Why someone likes to act like that, nobody knows."

Missing Alaska Barista Had Past Restraining Order Watch Video

Authorities described the murders of the Curriers in great detail, offering insight into how the twisted killer traveled to murder, his criteria for choosing random victims and his careful planning of of the murders.

"When [Keyes] left Alaska, he left with the specific purpose of kidnapping and murdering someone," Chittenden County State Attorney T. J. Donovan said at the press conference. "He was specifically looking for a house that had an attached garage, no car in the driveway, no children, no dog."

The Curriers, unfortunately, fit all of Keyes' criteria. He spent three days in Vermont before striking. He even took out a three-day fishing license and fished before the slayings.

In June 2011, Keyes went to their house and cut a phone line from outside and made sure they did not have a security system that would alert police. He donned a head lamp and broke into their house with a gun and silencer that he had brought with him.

Keyes found the couple in bed and tied them up with zip ties. He took Lorraine Currier's purse and wallet as well as Bill Currier's gun. He left the man's wallet.

He put the couple in their own car and drove them to an abandoned farmhouse that he had previously scoped out. Keyes tied Bill Currier to a stool in the basement and went back to the car for Lorraine Currier.

"Keyes saw that Lorraine had broken free from the zip ties and observed that she was running towards Main Street," Donovan said. "He tackled her to regain control of her."

Keyes took Lorraine Currier to the second floor of the farmhouse and tied her up. He rushed to the basement when he heard commotion and found that Bill Currier's stool had broken and he was partially free.

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Syrian spokesman flees country, diplomat says

CAIRO/BEIRUT (Reuters) - A Syrian foreign ministry spokesman, who was the most public face of Bashar al-Assad's government as it battled a 20-month-old uprising, has fled the country, a diplomat in the region said on Monday.

Jihad al-Makdissi, who is in his 40s, previously worked at the Syrian embassy in London and returned to Damascus a year ago to serve as spokesman for the ministry, defending the government's crackdown on the revolt against Assad's rule.

He had little influence in a system largely run by the security apparatus and the military. But Assad's opponents will see the loss of such a high profile figure, if confirmed, as further evidence of a system crumbling from within.

Rebel forces have made advances in recent weeks, seizing military bases including some close to the capital Damascus. Amid talk that troops had moved chemical weapons, U.S. President Barack Obama again warned Assad against using them.

Makdissi belongs to Syria's Christian minority, which has largely stood behind Assad. He worked with the foreign ministry for 10 years and speaks fluent English, a rarity in a state apparatus shaped by the Baath Party's anti-Western ideology.

"He defected. All I can say is that he is out of Syria," the diplomatic source, who did not want to be named, told Reuters.

Lebanon's al-Manar Television, citing government sources, said Makdissi was sacked for making statements that did not reflect the government's position.

He was rarely seen in the media in recent weeks. His mobile telephone was switched off and there was no immediate comment in Syrian state media. The pan-Arab news channel Al Arabiya said Makdissi had left Beirut and was on his way to London, where he was expected to remain.

"We're aware of reports that he has defected and may be coming to the UK. We're seeking clarification," a Foreign Office spokeswoman said.

CHEMICAL WEAPONS

Rebels have begun to advance more quickly after months of slow sieges to cut off army routes and supplies. In the past few weeks, they seized several military bases, and are now using anti-aircraft weapons to attack the military helicopters and fighter jets that had bombarded their positions with impunity.

Media reports citing European and U.S. officials said Syria's chemical weapons had been moved and could be prepared for use in response - long a fear raised by the opposition.

White House spokesman Jay Carney said U.S. concerns about Syria's intentions regarding the use of chemical weapons were increasing, prompting Washington to make contingency plans.

Syria said it would not use chemical weapons against its own people: "Syria has stressed repeatedly that it will not use these types of weapons, if they were available, under any circumstances against its people," the foreign ministry said.

Obama, who has steered clear of repeating in Syria the kind of military engagements Washington has seen in Iraq, Afghanistan or Libya, later repeated a warning to Assad - vaguely worded - against using chemical weapons to keep himself in power:

"The world is watching," Obama said. "The use of chemical weapons is and would be totally unacceptable and if you make the tragic mistake of using these weapons there will be consequences and you will be held accountable."

DAMASCUS BATTLES

The army appears to have focused most of its energy on Damascus, where rebels have been planning to push into the capital from the surrounding suburbs.

The military has been trying to seal off the city, using heavy bombardment and air raids to try to drive rebels back. Over 56 people were killed around Damascus alone on Sunday, with 200 dead across the country.

Damascus itself has not been free of unrest. Rebel-held southern districts have been bombarded heavily, activists say. The Syrian Observatory for Human Rights reported fierce clashes around the Tishreen military hospital in the northern Barzeh district and a car bomb in the southern area of Tadamon.

Neither side appears to have the upper hand in the fighting around Damascus. A previous attempt by rebels last July to hold ground in the city was crushed, but the fighters fell back into the suburbs and nearby countryside.

Clashes and tensions also remain high around Damascus International Airport and along the airport highway, which has become an on-and-off battleground that forced foreign airlines to suspend flights to Damascus since Thursday evening.

EgyptAir, which tried to resume flights on Monday, had to call back a plane headed to Damascus due to the "bad security situation" around the airport, an airline official said.

The conflict has grown increasingly bloody in recent months, as rebels began to contest Assad's power around the capital as well as in Aleppo, Syria's largest city. More than 40,000 people have died in the conflict, with hundreds more killed each week.

The United Nations said on Monday it was withdrawing "all non-essential international staff" from Syria because of deteriorating security, and was restricting remaining staff to Damascus. It said more armored vehicles were needed following attacks on humanitarian aid convoys sometimes caught in the crossfire.

A European Union official said the EU was pulling international staff from Damascus because of the security situation and its ambassador to Syria had ended his posting.

(Editing by Philippa Fletcher and Alastair Macdonald; Reporting by Khaled Yacoub Oweis, Erika Solomon, Additional reporting by Mohammed Abbas; Editing by Michael Roddy)

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Police raid highway operator over Japan tunnel collapse

TOKYO: Japanese police on Tuesday raided offices belonging to a highway operator over a weekend tunnel collapse that killed nine people.

More than eight officers from the Yamanashi Police Department entered the office of NEXCO in Hachioji, western Tokyo, a spokesman for the highway operator said.

"We are fully cooperating with the authorities over the accident," the spokesman told AFP.

Police also plan to raid more of the company's offices in connection with the tragedy at the Sasago tunnel, which passes through hills near Mount Fuji, Japanese broadcaster NHK said.

On Monday, the Japanese government ordered inspections of ageing highway tunnels following the accident as suspicion over the cause of the accident centred on decaying ceiling supports.

- AFP/fa/ck

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Shimla takes first step towards modern transportation

SHIMLA: Shimla residents can now hope to get a new transportation system in the near future with Global Energy Basil (GBL) of Germany, a partner of European Union, showing keen interest in Rs 3,000cr comprehensive mobility plan prepared by Shimla municipal corporation. Having shortlisted Shimla for funding purpose, GBL has invited Shimla municipal corporation for presentation in January.

Shimla town faces a serious problem of traffic congestion due to peculiar geography and age-old construction. The road infrastructure was created during the British rule to cater to the needs of the then population, and little progress has been made till now. With the passage of time, increase in population and inflow of tourists further increased the problems.

To decongest Shimla, Himachal Pradesh government has decided to form satellite towns on the outskirts to save original character of the city which otherwise is bursting at seams with over-population and over-construction. Three satellite towns have been proposed at Vaknaghat on Shimla-Chandigarh highway, Fagu on Shimla-Rampur highway and Ghandal in-between Ghanahatti and Shalaghat on Shimla-Bilaspur highway.

If GBL agrees to fund the comprehensive mobility plan of Shimla, the city would get relief from traffic congestion and pollution. Sources said that GBL has already funded around 40 such projects in other parts of the world, including Beijing, Kampala and Islamabad.

Comprehensive mobility plan submitted to Global Energy Basil has provision of regulating 48,000 vehicles in the city in a planned manner. Submitted plan has the provision for ropeways at the cost of $623 million and tunnels estimated at $63 million, sources said.

Confirming the development, municipal commissioner Dr M P Sood said that acceptance of proposal by GBL is a big success. "For the first time, a mega project has been planned for Shimla and in January, a presentation would be made to GBL during its annual convention," he said.

Sood said that after Kochin, Shimla is second city in India where GBL has shown interest to fund the project. "The project envisages cable ropeways, mono rail, widening of existing corridors and construction of escalators," he said.

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Fossil fuel subsidies in focus at climate talks

DOHA, Qatar (AP) — Hassan al-Kubaisi considers it a gift from above that drivers in oil- and gas-rich Qatar only have to pay $1 per gallon at the pump.

"Thank God that our country is an oil producer and the price of gasoline is one of the lowest," al-Kubaisi said, filling up his Toyota Land Cruiser at a gas station in Doha. "God has given us a blessing."

To those looking for a global response to climate change, it's more like a curse.

Qatar — the host of U.N. climate talks that entered their final week Monday — is among dozens of countries that keep gas prices artificially low through subsidies that exceeded $500 billion globally last year. Renewable energy worldwide received six times less support — an imbalance that is just starting to earn attention in the divisive negotiations on curbing the carbon emissions blamed for heating the planet.

"We need to stop funding the problem, and start funding the solution," said Steve Kretzmann, of Oil Change International, an advocacy group for clean energy.

His group presented research Monday showing that in addition to the fuel subsidies in developing countries, rich nations in 2011 gave more than $58 billion in tax breaks and other production subsidies to the fossil fuel industry. The U.S. figure was $13 billion.

The Paris-based Organization for Economic Cooperation and Development has calculated that removing fossil fuel subsidies could reduce carbon emissions by more than 10 percent by 2050.

Yet the argument is just recently gaining traction in climate negotiations, which in two decades have failed to halt the rising temperatures that are melting Arctic ice, raising sea levels and shifting weather patterns with impacts on droughts and floods.

In Doha, the talks have been slowed by wrangling over financial aid to help poor countries cope with global warming and how to divide carbon emissions rights until 2020 when a new planned climate treaty is supposed to enter force. Calls are now intensifying to include fossil fuel subsidies as a key part of the discussion.

"I think it is manifestly clear ... that this is a massive missing piece of the climate change jigsaw puzzle," said Tim Groser, New Zealand's minister for climate change.

He is spearheading an initiative backed by Scandinavian countries and some developing countries to put fuel subsidies on the agenda in various forums, citing the U.N. talks as a "natural home" for the debate.

The G-20 called for their elimination in 2009, and the issue also came up at the U.N. earth summit in Rio de Janeiro earlier this year. Frustrated that not much has happened since, European Union climate commissioner Connie Hedegaard said Monday she planned to raise the issue with environment ministers on the sidelines of the talks in Doha.

Many developing countries are positive toward phasing out fossil fuel subsidies, not just to protect the climate but to balance budgets. Subsidies introduced as a form of welfare benefit decades ago have become an increasing burden to many countries as oil prices soar.

"We are reviewing the subsidy periodically in the context of the total economy for Qatar," the tiny Persian gulf country's energy minister, Mohammed bin Saleh al-Sada, told reporters Monday.

Qatar's National Development Strategy 2011-2016 states it more bluntly, saying fuel subsides are "at odds with the aspirations" and sustainability objectives of the wealthy emirate.

The problem is that getting rid of them comes with a heavy political price.

When Jordan raised fuel prices last month, angry crowds poured into the streets, torching police cars, government offices and private banks in the most sustained protests to hit the country since the start of the Arab unrest. One person was killed and 75 others were injured in the violence.

Nigeria, Indonesia, India and Sudan have also seen violent protests this year as governments tried to bring fuel prices closer to market rates.

Iran has used a phased approach to lift fuel subsidies over the past several years, but its pump prices remain among the cheapest in the world.

"People perceive it as something that the government is taking away from them," said Kretzmann. "The trick is we need to do it in a way that doesn't harm the poor."

The International Energy Agency found in 2010 that fuel subsidies are not an effective measure against poverty because only 8 percent of such subsidies reached the bottom 20 percent of income earners.

The IEA, which only looked at consumption subsidies, this year said they "remain most prevalent in the Middle East and North Africa, where momentum toward their reform appears to have been lost."

In the U.S., environmental groups say fossil fuel subsidies include tax breaks, the foreign tax credit and the credit for production of nonconventional fuels.

Industry groups, like the Independent Petroleum Association of America, are against removing such support, saying that would harm smaller companies, rather than the big oil giants.

In Doha, Mohammed Adow, a climate activist with Christian Aid, called all fuel subsidies "reckless and dangerous," but described removing subsidies on the production side as "low-hanging fruit" for governments if they are serious about dealing with climate change.

"It's going to oil and coal companies that don't need it in the first place," he said.

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Associated Press writers Abdullah Rebhy in Doha, Qatar, and Brian Murphy in Dubai, United Arab Emirates, contributed to this report

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Karl Ritter can be reached at www.twitter.com/karl_ritter

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