India misguided, paranoid over China: Guha

MUMBAI: A good half-hour into the discussion on 'India, China and the World', historian Ramachandra Guha issued a disclaimer—all the three members on the panel had been to China only once. "We should learn their language, promote quality research, and have a panel on China driven by Chinese scholars," he said. And that was the general tenor of the debate—that the Indian attitude to China was influenced by a mix of ignorance, cautious optimism about partnerships and a whole lot of misguided paranoia. "Don't demonise the Chinese, please," Guha finally said in response to a question.

"China has existed in our imaginations," observed Sunil Khilnani, professor of politics and author of The Idea Of India. "There's been very little sustained engagement with the reality of China and very little of our own produced knowledge about China." It was after the events of 1962 ('war' in the popular imagination, 'skirmish' to the scholars participating in the discussion), explained Khilnani, that a miffed India "withdrew". It's the 50th anniversary of that exchange this year, and "what we haven't been able to do is learn from the defeat", observed Khilnani. Both could have benefited from greater engagement. "China has had a very clear focus on primary education and achieved high levels of literacy before its economic rise. It has also addressed the issue of land reform," said Khilnani. Guha added that China could learn from the "religious, cultural and linguistic pluralism" in India.

But China and India weren't always so out of sync with each other. Srinath Raghavan, a scholar of military history, got both Guha and Khilnani to talk about pre-1962 relations between the two when the picture was rosier. Tagore was interested in China and so was Gandhi. Both were very large countries with large populations and shared what Guha calls a "lack of cultural inferiority". "They were both," he continued, "also heavily dependent on peasant communities." Nehru was appreciative of China's will to modernize and industrialize and its adoption of technology to achieve those ends. In turn, Chinese politicians argued for Indian independence.

Things soured more, feel both Khilnani and Guha, after the Dalai Lama fled to India in 1959. "He was welcomed here as a spiritual leader but the intensification of the conflict dates to the Dalai Lama's flight," said Guha. Both Guha and Khilnani argued that Nehru's decision to not react aggressively to China's occupation of Tibet was, in the long run, the right one and prevented further "militarization" of the region. An audience member wondered if that didn't make India "China's puppet". Guha disagreed. "If there's a Tibetan culture alive today," he said, "it's not because of Richard Gere. Don't believe in the hypocrisy of the Western countries. Will they give them land, employment, dignified refuge? The Tibetans is one of the few cases in which our record is honorable."

But the difference in levels of development and the lopsided trade relations between the two countries have only fuelled the suspicions many Indians seem to harbour about China. People were worried, said Guha, even about cricket balls made in China. Audience questions reflected those worries. A member asked about China's "strategy to conquer the world" and its likely impact on India. Guha cautioned against stereotypes; Khilnani explained, "History is littered with the debris of states that have tried to dominate the world. What we're doing may be more long-lasting."

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Smokers celebrate as Wash. legalizes marijuana


SEATTLE (AP) — The crowds of happy people lighting joints under Seattle's Space Needle early Thursday morning with nary a police officer in sight bespoke the new reality: Marijuana is legal under Washington state law.


Hundreds gathered at Seattle Center for a New Year's Eve-style countdown to 12 a.m., when the legalization measure passed by voters last month took effect. When the clock struck, they cheered and sparked up in unison.


A few dozen people gathered on a sidewalk outside the north Seattle headquarters of the annual Hempfest celebration and did the same, offering joints to reporters and blowing smoke into television news cameras.


"I feel like a kid in a candy store!" shouted Hempfest volunteer Darby Hageman. "It's all becoming real now!"


Washington and Colorado became the first states to vote to decriminalize and regulate the possession of an ounce or less of marijuana by adults over 21. Both measures call for setting up state licensing schemes for pot growers, processors and retail stores. Colorado's law is set to take effect by Jan. 5.


Technically, Washington's new marijuana law still forbids smoking pot in public, which remains punishable by a fine, like drinking in public. But pot fans wanted a party, and Seattle police weren't about to write them any tickets.


In another sweeping change for Washington, Gov. Chris Gregoire on Wednesday signed into law a measure that legalizes same-sex marriage. The state joins several others that allow gay and lesbian couples to wed.


The mood was festive in Seattle as dozens of gay and lesbian couples got in line to pick up marriage licenses at the King County auditor's office early Thursday.


King County and Thurston County announced they would open their auditors' offices shortly after midnight Wednesday to accommodate those who wanted to be among the first to get their licenses.


Kelly Middleton and her partner Amanda Dollente got in line at 4 p.m. Wednesday.


Hours later, as the line grew, volunteers distributed roses and a group of men and women serenaded the waiting line to the tune of "Chapel of Love."


Because the state has a three-day waiting period, the earliest that weddings can take place is Sunday.


In dealing with marijuana, the Seattle Police Department told its 1,300 officers on Wednesday, just before legalization took hold, that until further notice they shall not issue citations for public marijuana use.


Officers will be advising people not to smoke in public, police spokesman Jonah Spangenthal-Lee wrote on the SPD Blotter. "The police department believes that, under state law, you may responsibly get baked, order some pizzas and enjoy a 'Lord of the Rings' marathon in the privacy of your own home, if you want to."


He offered a catchy new directive referring to the film "The Big Lebowski," popular with many marijuana fans: "The Dude abides, and says 'take it inside!'"


"This is a big day because all our lives we've been living under the iron curtain of prohibition," said Hempfest director Vivian McPeak. "The whole world sees that prohibition just took a body blow."


Washington's new law decriminalizes possession of up to an ounce for those over 21, but for now selling marijuana remains illegal. I-502 gives the state a year to come up with a system of state-licensed growers, processors and retail stores, with the marijuana taxed 25 percent at each stage. Analysts have estimated that a legal pot market could bring Washington hundreds of millions of dollars a year in new tax revenue for schools, health care and basic government functions.


But marijuana remains illegal under federal law. That means federal agents can still arrest people for it, and it's banned from federal properties, including military bases and national parks.


The Justice Department has not said whether it will sue to try to block the regulatory schemes in Washington and Colorado from taking effect.


"The department's responsibility to enforce the Controlled Substances Act remains unchanged," said a statement issued Wednesday by the Seattle U.S. attorney's office. "Neither states nor the executive branch can nullify a statute passed by Congress."


The legal question is whether the establishment of a regulated marijuana market would "frustrate the purpose" of the federal pot prohibition, and many constitutional law scholars say it very likely would.


That leaves the political question of whether the administration wants to try to block the regulatory system, even though it would remain legal to possess up to an ounce of marijuana.


Alison Holcomb is the drug policy director of the American Civil Liberties Union of Washington and served as the campaign manager for New Approach Washington, which led the legalization drive. She said the voters clearly showed they're done with marijuana prohibition.


"New Approach Washington sponsors and the ACLU look forward to working with state and federal officials and to ensure the law is fully and fairly implemented," she said.


___


Johnson can be reached at https://twitter.com/GeneAPseattle


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Not 'Wild West': Talking Cyber Ops at Iran's Backdoor












Robert Clark, the operational attorney for U.S. Cyber Command, stood in a grand ballroom with gold flaked ceilings and sparkling chandeliers to address an audience that included men in flowing white robes and veiled women and tried to hammer home a single point: cyber warfare is not the "Wild West."


Clark, who emphasized that he was speaking only in a personal capacity and not on behalf of the U.S. government, wanted to assure the relatively small gathering in the United Arab Emirates that in an age where a new "revolutionary" cyber weapon like Stuxnet is discovered every few months -- usually on computers in Iran, just across the Arabian Gulf -- legal considerations are taken into account before cyber attacks are launched.


"Articles that talk about cyber warfare and [say] that rules of engagement aren't evolving as fast as [the cyber attacks], it's just not true," Clark said. "We have the law of armed conflict applying to any type conflict and it applies to cyberspace operations also... It's just not the Wild West out there."




For most of his presentation, Clark spoke in generalities about the legal aspects of American cyber capabilities because despite the months-old admission from his boss, U.S. Cyber Command chief Gen. Keith Alexander, that the military is developing a "pro-active, agile cyber force," and the oft-cited New York Times report on America's role in developing Stuxnet, the devastating cyber weapon that hit an Iranian nuclear facility in late 2009, no current American officials have gone on record claiming responsibility for an offensive cyber attack.


However, emboldened by a government colleague's praise of Stuxnet earlier this year, Clark couldn't resist using it as a hypothetical example.


He said that before a weapon like Stuxnet would be launched, the same legal criteria would be considered as if it were a physical military attack. Is there an imminent threat from the target? Does it absolutely have to be taken out? Will the attack cause casualties or collateral damage that could and should be avoided?


Answering his own question about casualties, Clark echoed comments from colleague Air Force Col. Gary Brown when he noted the impressive restraint of the worm. Though Stuxnet was discovered on thousands of computers around the world in 2010, cyber researchers quickly realized that it was something of a smart bomb. It would spread harmlessly from computer to computer until it found itself on the exact system configuration -- a control system at an Iranian nuclear facility -- it was meant to target.


"Stuxnet," Clark said, "was a very discriminant weapon."


After Stuxnet was discovered and analyzed, Richard Clarke, a former White House counter-terrorism adviser and current ABC News consultant, said he thought that Stuxnet showed such care to limit collateral damage that it must have been developed with healthy input from anxious lawyers.


Robert Clark's presentation Wednesday was one of the first talks at the Black Hat security conference held at the opulent Emirate Palace Hotel in Abu Dhabi and though most of the presentations were highly technical, Clark wasn't the first and or the last to talk about the cyber struggle over Iran.






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Egypt demonstrators reject Mursi call for dialogue


CAIRO (Reuters) - Demonstrators rejected a call from Egypt's Islamist President Mohamed Mursi for a national dialogue after deadly clashes around his palace, demanding the "downfall of the regime" - the chant that brought down Hosni Mubarak.


Mursi said in a televised speech late on Thursday that plans were on track for a referendum on a new constitution on December 15 despite clashes that killed seven people. He proposed a meeting on Saturday with political leaders, "revolutionary youth" and legal figures to discuss the way forward after that.


But a leading activist group rejected the offer, and fresh demonstrations were called for Friday.


The "April 6" movement, which played a prominent role in igniting the revolt against Mubarak said on its Facebook page that Friday's protests would deliver a "red card" to Mursi.


Egypt has been plunged into turmoil since Mursi issued a decree on November 22 awarding himself wide powers and shielding his decisions from judicial review.


His Islamist supporters say the decree was necessary to prevent Mubarak-era judges from interfering with reforms. A constitution drawn up by a body dominated by Islamists is due to be put to a referendum next week.


The opposition has demanded that Mursi scrap his decree, postpone the referendum and redraft the constitution.


In his address, Mursi said: "I call for a full, productive dialogue with all figures and heads of parties, revolutionary youth and senior legal figures to meet this Saturday."


Several thousand opposition protesters near the palace waved their shoes in derision after his speech and shouted "Killer, killer" and "We won't go, he will go" - another of the slogans used against Mubarak in last year's revolt.


The Cairo headquarters of the Muslim Brotherhood, the group that propelled Mursi to victory in a June election, was set ablaze. Other offices of its political party were attacked.


TENTATIVE CONCESSION


The United States, worried about the stability of an Arab partner which has a peace deal with Israel and which receives $1.3 billion a year in U.S. military aid, had urged dialogue.


Mursi said his entire decree would lapse after the constitutional referendum, regardless of its result.


He said a new constituent assembly would be formed to redraft the constitution if Egyptians rejected the one written in the past six months.


The Republican Guard, an elite unit whose duties include protecting the presidential palace, restored peace on Thursday after a night of violence outside the palace, ordering rival demonstrators to leave by mid-afternoon.


Mursi supporters withdrew, but opposition protesters remained, kept away by a barbed wire barricade guarded by tanks. By evening their numbers had swelled to several thousand.


Thousands of supporters and opponents of Mursi had fought well into Thursday's early hours, using rocks, petrol bombs and guns. Officials said 350 were wounded in the violence. Six of the dead were Mursi supporters, the Muslim Brotherhood said.


Opposition groups have called for protests after Friday prayers aimed at "the downfall of the militia regime", a dig at what they see as the Brotherhood's organized street muscle.


A communique from a leftist group urged protesters to gather at mosques and squares across Egypt, and to stage marches in Cairo and its sister city Giza, converging on the presidential palace. "Egyptian blood is a red line," the communique said.


Hardline Islamist Salafis also summoned their supporters to protest against what they consider biased coverage of the crisis by some private Egyptian satellite television channels.


Since Mursi issued his decree, six of his advisers have resigned. Essam al-Amir, the director of state television, quit on Thursday, as did a Christian official at the presidency.


The Brotherhood's supreme guide, Mohamed Badie, called for unity, saying divisions "only serve the nation's enemies".


The Islamists, who have won presidential and parliamentary elections since Mubarak was overthrown, are confident they can win the referendum and the parliamentary election to follow.


As well as relying on his Brotherhood power base, Mursi may also tap into a popular yearning for stability and economic revival after almost two years of political turmoil.


Egypt's pound hit an eight-year low on Thursday, reversing gains made on hopes that a $4.8 billion IMF loan would stabilize the economy. The stock market fell 4.6 percent.


(Additional reporting by Edmund Blair and Marwa Awad; Writing by Alistair Lyon and Peter Graff; Editing by Louise Ireland)



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Bieber miffed at Grammys snub, Brubeck gets nod






LOS ANGELES: Justin Bieber's manager has lambasted the Grammys organisers after the Canadian teen sensation failed to garner a single nomination for this year's music awards.

At the other end of the musical spectrum, late jazz icon Dave Brubeck was honoured with a posthumous nod for the music industry's top prizes, in a little-noticed category at Wednesday night's nominations show.

"The kid deserved it. Grammy board u blew it on this one," tweeted the Bieb's manager Scooter Braum, after the Recording Academy failed to nominate him in any of its 81 categories.

"The kid delivered. Huge successful album, sold out tour, and won people over... this time he deserved to be recognized and I don't really have any kind nice positive things to say about a decision I don't agree with."

And he added: "To his fans... looks like we get to stay the underdog a little longer."

This year's Grammy nominees were announced at a one-hour show in Nashville on Wednesday night, with New York indie pop band fun. picking up six Grammy nominations in its breakout year.

Others with multiple nods for Grammy gongs, to be awarded on February 10 in Los Angeles, included rap artist Frank Ocean, The Black Keys, British rock-folk group Mumford & Sons and ex White Stripes rocker Jack White.

Wednesday's show included a brief mention for jazz pianist and composer Brubeck, hours after he died just short of his 92nd birthday.

Brubeck, whose 1959 album "Time Out" became the first million-selling jazz record of the modern era, with classics like "Take Five" and "Blue Rondo a la Turk", already won a Grammy Lifetime Achievement Award in 1996.

But he had never won an individual category Grammy.

That may change in February, after he was shortlisted for Best Instrumental Composition for "Music of Ansel Adams: America", a 22-minute piece inspired by the late photographer and environmentalist's famous black-and-white prints.

Brubeck's son Chris, credited as joint composer, brought the concept to his father who wrote it as a piano score, before his son reworked it into a full orchestral piece, according to industry weekly Billboard.

-AFP/fl



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Tribal women wage war against IMFL

SHIMLA: Tribal women in Lahaul-Spiti and Kinnaur district have waged a unique war to curb social inequality, especially during marriages and other social functions. In a bid to curb show of wealth, women have come up with unique idea of banning the use of English liquor and those defying ban are being imposed heavy penalty.

Liquor is an important part of tribal customs and social get together are incomplete if alcohol and mutton are not served to guests. Since ages, tribals in Kinnaur are brewing liquor locally known as "angoori" while in Lahaul-Spiti they make it from wheat. But with the coming of wealth locally brewed liquor was replaced by whisky and beer resulting into social inequality widening the gap between rich and poor.

Noted social activist of Kinnaur and chairperson of Kinnaur Mahila Kalyan Parishad Ratan Manjari said over the years serving English liquor and beer during marriages and other social functions had become a show of wealth and those not having money too were serving it and get burdened with debt. "Trend was wrong which needed to be stopped and now we have done it in many villages of Kinnaur," she said. Kinnaur Mahila Kalyan Parishad has 200 mahila mandals as its members.

Ratan Manjari said for 5-6 years, they have mobilized support of women in Kinnaur district to tell them how use of English liquor and beer during marriages is resulting in waste of money besides creating divide among rich and poor. "Today, we have succeeded in banning English liquor in social functions, especially in Kalpa, Sangla, Lippa and other areas of district," she said.

To ensure that people obey the decision, a provision of imposing fine has been made by women amicably. "We have decided to impose penalty of Rs 5,000 on people serving the English liquor and those consuming it," Manjari said. She said still a lot more is required to be done.

In Lahaul-Spiti district, Udaipur village is setting an example for others by observing complete ban on English liquor and beer during social gathering for last three years. "During marriages and other functions only locally made liquor is served. Those defying ban are punished by mahila mandal members," said Hemvati, Mahila Mandal member of Udaipur.

Hemvati said if a family in the village found serving English liquor and Beer despite ban, then Rs 10,000 fine is imposed, but if same offence is committed second time then the family is boycotted socially.

"Such decisions are in larger interest of society as seeing rich people serving liquor even poor were following the trend after borrowing money. In one wedding, people were usually spending Rs 50,000 to 1 lakh only on liquor, but now with ban enforced in many villages show of wealth has been curbed in the interest of poor," said Rigzin Samphel Hayerpa, Zila Parishad member from Kolang in Lahaul-Spiti.

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Bodies Found in Hunt for Missing Iowa Cousins













Nearly five months after Iowa cousins Lyric Cook and Elizabeth Collins disappeared, the girls' families have been told two bodies were found by hunters in a wooded area, though the identities of the bodies have not been confirmed, authorities said.


Capt. Rick Abben of the Black Hawk County Sheriff's Office said at a press conference this afternoon that the bodies are being transported to the state's medical office in Ankeny, Iowa, for positive identification.


"It's definitely not the outcome that we wanted, obviously," Abben said. "This is a difficult thing for us to go through."


Lyric, 11, and Elizabeth , 9, vanished shortly after noon on July 13 while on a bike ride in the small town of Evansdale, Iowa, triggering a massive search that brought the town to a standstill. The girls' bicycles and a purse were quickly found near Meyers Lake, but there was no sign of the girls.


PHOTOS From ABC News Affiliate KCRG: The Search for Lyric & Elizabeth






Black Hawk County Police/AP Photo











Missing Iowa Girls Seen Riding Bikes on Surveillance Video Watch Video









Missing Iowa Girls: One Mother Takes 2nd Polygraph Watch Video







On the two-month anniversary of the girls' disappearance, local residents held a prayer vigil and authorities urged members of the public to provide any new information that might help them solve the case.


Authorities said the girls left Elizabeth's house in Evansdale around 12:15 p.m., were spotted at approximately 12:23 p.m. at a nearby intersection and then were seen between 12:30 and 1 p.m. on a road by the lake.


During the following week, authorities canvassed the area and drained the town's lake. Lyric's estranged parents, Misty and Dan Morrissey, at one point became the subject of intense police scrutiny because of their criminal pasts and their lack of cooperation.


Over the summer, the families received a boost when Elizabeth Smart, one of the country's most famous kidnapping survivors, offered some words of encouragement. Police found Smart after a nine-month search in Utah a decade ago.


"For as many bad things that we hear about that happen, for as many kidnappings and terrible stories about finding the remains of children, why can't these girls be the exception?" Smart told the Des Moines Register.


Elizabeth's mother, Heather Collins, told ABC News' Alex Perez in July that the wait for the girls to reappear was an agonizing one.


"A day doesn't seem like a normal day," Collins said. "It's just like it doesn't stop. It keeps dragging and dragging. You're just waiting for a time to go up to your room. You're just waiting, waiting, waiting."


"Whoever's out there, we're just begging you to bring our girls back home," she said.


A $50,000 reward had been offered for information that led to the arrest and conviction of the person responsible for the girls' disappearance.



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Critics give epic 'Hobbit' middle marks






NEW YORK: Peter Jackson's "The Hobbit: An Unexpected Journey" opens in the US this month and critics say the movie, much like the epic journey it depicts, is adventurous - but an uphill slog.

The fantasy about a Hobbit called Bilbo Baggins, Gandalf the good wizard, 13 raucous dwarves, and a host of evil forces, takes viewers back to the lavishly filmed Middle-earth world that won Oscars and rave reviews in Jackson's previous "Lord of the Rings" trilogy.

But reviews from journalists, who got to see the nearly three-hour movie ahead of its December 14 US premiere, were also somewhere in the middle.

Jackson's technical wizardry, using 3D and 48 frames a second, rather than the ordinary 24 frames, got gasps of admiration, mixed with yawns about overkill.

And while the New Zealand-born director scored high marks for the faithfulness of the adaption from J.R.R. Tolkien's book, there was incredulity - and some cynicism - about the decision to split the relatively slender "Hobbit" into three enormous movies.

"In Jackson's academically fastidious telling, however, it's as if 'The Wizard of Oz' had taken nearly an hour just to get out of Kansas," The Hollywood Reporter said in a bruising review.

"There are elements in this new film that are as spectacular as much of the Rings trilogy was, but there is much that is flat-footed and tedious as well."

Variety's critic took aim at the overwhelming detail poured into 48-frames-a-second pictures.

"Everything takes on an overblown, artificial quality in which the phoniness of the sets and costumes becomes obvious, while well-lit areas bleed into their surroundings, like watching a high-end home movie," Variety said.

"The Hobbit", which was screened for journalists in New York on Tuesday, is a prequel to the darker "Lord of the Rings," introducing the main characters and plot lines that reappear through the entire saga. The cursed golden ring also makes its first appearance.

There are bravura battle scenes, choreographed hordes of Goblins, fantastical caves, and James Bond-style narrow escapes from death for Martin Freeman's Bilbo Baggins and his dwarf friends. As in the three "Rings" movies, the natural settings of New Zealand are breath-taking.

But with so many strange beings attacking each other with swords, and so many arrows, rocks and bodies flying in 3D at the audience, the few intimately staged scenes focusing on just a couple characters can come as a relief.

When the action cut suddenly from the latest mass sword fight to a silent cave inhabited by Andy Serkis' creepy character Gollum, journalists at Tuesday's press screening broke out in a rare smattering of applause.

Jackson defended the decision to stretch the book to three movies, in contrast to the "Rings" trilogy, which was based on three books.

He told reporters Wednesday in New York that in Tolkien's often "breathless" text, "very major events are covered in two or three pages," and that transferring the action to film required a more sumptuous treatment.

Screenwriter and co-producer Philippa Boyens said the different pace responded to the dynamics of working with actors.

"Great actors come to you for the material and if you give them very slight material, you're just not going to get them. We wanted to write for these great actors," she said.

The filmmakers also defended their use of the 48 frames a second. "Fantasy should be as real as possible," Jackson said, "The levels of detail are very important."

The reviews for "The Hobbit" were far from universally negative, and many critics said the three films may well make healthy profits. On the reviews aggregator website Rotten Tomatoes, the rating of fresh versus rotten tomatoes was a high 78 percent Wednesday.

Great British actor Ian McKellen, who reprised his "Rings" role as Gandalf in "The Hobbit", batted down suggestions that the filmmakers were trying to milk the maximum profit out of Tolkien fans.

"Anyone who thinks Peter Jackson would fall for market forces, instead of artistic imperatives, just doesn't know him, doesn't know the body of his work," McKellen told reporters.

The movies will do well because Bilbo Baggins and his travails are a universal story, he said.

"It's about the little guy that we need and may be expendable, who may not come back."

-AFP/fl



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Study could spur wider use of prenatal gene tests


A new study sets the stage for wider use of gene testing in early pregnancy. Scanning the genes of a fetus reveals far more about potential health risks than current prenatal testing does, say researchers who compared both methods in thousands of pregnancies nationwide.


A surprisingly high number — 6 percent — of certain fetuses declared normal by conventional testing were found to have genetic abnormalities by gene scans, the study found. The gene flaws can cause anything from minor defects such as a club foot to more serious ones such as mental retardation, heart problems and fatal diseases.


"This isn't done just so people can terminate pregnancies," because many choose to continue them even if a problem is found, said Dr. Ronald Wapner, reproductive genetics chief at Columbia University Medical Center in New York. "We're better able to give lots and lots of women more information about what's causing the problem and what the prognosis is and what special care their child might need."


He led the federally funded study, published in Thursday's New England Journal of Medicine.


A second study in the journal found that gene testing could reveal the cause of most stillbirths, many of which remain a mystery now. That gives key information to couples agonizing over whether to try again.


The prenatal study of 4,400 women has long been awaited in the field, and could make gene testing a standard of care in cases where initial screening with an ultrasound exam suggests a structural defect in how the baby is developing, said Dr. Susan Klugman, director of reproductive genetics at New York's Montefiore Medical Center, which enrolled 300 women into the study.


"We can never guarantee the perfect baby but if they want everything done, this is a test that can tell a lot more," she said.


Many pregnant women are offered screening with an ultrasound exam or a blood test that can flag some common abnormalities such as Down syndrome, but these are not conclusive.


The next step is diagnostic testing on cells from the fetus obtained through amniocentesis, which is like a needle biopsy through the belly, or chorionic villus sampling, which snips a bit of the placenta. Doctors look at the sample under a microscope for breaks or extra copies of chromosomes that cause a dozen or so abnormalities.


The new study compared this eyeball method to scanning with gene chips that can spot hundreds of abnormalities and far smaller defects than what can be seen with a microscope. This costs $1,200 to $1,800 versus $600 to $1,000 for the visual exam.


In the study, both methods were used on fetal samples from 4,400 women around the country. Half of the moms were at higher risk because they were over 35. One-fifth had screening tests suggesting Down syndrome. One-fourth had ultrasounds suggesting structural abnormalities. Others sought screening for other reasons.


"Some did it for anxiety — they just wanted more information about their child," Wapner said.


Of women whose ultrasounds showed a possible structural defect but whose fetuses were called normal by the visual chromosome exam, gene testing found problems in 6 percent — one out of 17.


"That's a lot. That's huge," Klugman said.


Gene tests also found abnormalities in nearly 2 percent of cases where the mom was older or ultrasounds suggested a problem other than a structural defect.


Dr. Lorraine Dugoff, a University of Pennsylvania high-risk pregnancy specialist, wrote in an editorial in the journal that gene testing should become the standard of care when a structural problem is suggested by ultrasound. But its value may be incremental in other cases and offset by the 1.5 percent of cases where a gene abnormality of unknown significance is found.


In those cases, "a lot of couples might not be happy that they ordered that test" because it can't give a clear answer, she said.


Ana Zeletz, a former pediatric nurse from Hoboken, N.J., had one of those results during the study. An ultrasound suggested possible Down syndrome; gene testing ruled that out but showed an abnormality that could indicate kidney problems — or nothing.


"They give you this list of all the things that could possibly be wrong," Zeletz said. Her daughter, Jillian, now 2, had some urinary and kidney abnormalities that seem to have resolved, and has low muscle tone that caused her to start walking later than usual.


"I am very glad about it," she said of the testing, because she knows to watch her daughter for possible complications like gout. Without the testing, "we wouldn't know anything, we wouldn't know to watch for things that might come up," she said.


The other study involved 532 stillbirths — deaths of a fetus in the womb before delivery. Gene testing revealed the cause in 87 percent of cases versus 70 percent of cases analyzed by the visual chromosome inspection method. It also gave more information on specific genetic abnormalities that couples could use to estimate the odds that future pregnancies would bring those risks.


The study was led by Dr. Uma Reddy of the National Institute of Child Health and Human Development.


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Online:


Medical journal: http://www.nejm.org


___


Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP


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Tasting DNA-Altered Salmon That May Hit US Plates













Deep in the rain forests of Panama, in a secret location behind padlocked gates, barbed-wire fences and over a rickety wooden bridge, grows what could be the most debated food product of our time.


It may look like the 1993 hit movie "Jurassic Park," but at this real-life freshwater farm scientists are altering the genes not of dinosaurs -- but of fish.


They are growing a new DNA-altered saltwater fish in the mountains, far from the sea -- a salmon that could be the first genetically altered animal protein approved for the world to eat. If it is approved, this would be a landmark change for human food.


But it is one critics call "Frankenfish."


"The idea of changing an animal form, I think, is really creepy," said Gary Hirshberg, founder of Stonyfield Farm, an organic dairy farm. "When you move the DNA from a species into another species ... you create a new life form that's so new and so unique that you can get a patent for it."


And until now, AquaBounty, the multinational biotech company that for 20 years has been developing this giant fish, has kept it under close wraps.


The press has never been invited to its Prince Edward Island laboratory on the Canadian maritime coast, and its fish farm location in Panama has been kept secret out of fear of sabotage.


The Food and Drug Administration has seen it, but few from the outside. In fact, the last public tour of any kind was four years ago.










AquaBounty Creates 'Fort Knox for Fish'


ABC News was given exclusive access to see the facilities up close and an opportunity to taste this mysterious fish that FDA scientists say "is as safe as food from conventional Atlantic salmon," although have yet to officially approve it for public sale.


Ron Stotish, the president and CEO of AquaBounty Technologies, the company that created and hopes to market the eggs of this salmon to independent fish farms around the world, told ABC News it has employed bio-security measures, creating a "Fort Knox for fish," to ensure safety for the fish and prevent cross-contamination with the wild.


Entry to both facilities begins with body suits and iodine baths for shoes, which serves to keep the fish safe from germs.


Inside these protected tanks, America gets the first up-close look at the final product, the fish that has the food police up in arms.


"These are very healthy, beautiful Atlantic salmon," Stotish said.


With one big difference -- the growth rate of a regular salmon compared to that of an AquaBounty genetically modified fish.


While the AquaBounty fish do not grow to a size larger than normal salmon, they get to full size much faster, cutting costs for producers.


A normal-size 1-year-old Atlantic salmon averages 10 inches long, while the genetically modified fish at the same age is more than two times larger, coming in at 24 inches.


Salmon is the second most popular seafood in America. According to the National Oceanic and Atmospheric Administration, the average size of an Atlantic salmon is 28 inches to 30 inches and 8 pounds to 12 pounds after two years at sea.


How do they accomplish the accelerated growth?


"They differ by a single gene," Stotish said.


But, it's that single gene change that makes the DNA-altered salmon grow much faster than a normal Atlantic salmon, because it's really three fish in one.


AquaBounty scientists have taken a growth gene from the Chinook salmon and inserted it into the DNA of the Atlantic salmon because Chinooks grow fast from birth, while Atlantics do not.


"Salmon in their first two years of life grow very slowly," Stotish said.






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