Clues to why most survived China melamine scandal

WASHINGTON (AP) — Scientists wondering why some children and not others survived one of China's worst food safety scandals have uncovered a suspect: germs that live in the gut.

In 2008, at least six babies died and 300,000 became sick after being fed infant formula that had been deliberately and illegally tainted with the industrial chemical melamine. There were some lingering puzzles: How did it cause kidney failure, and why wasn't everyone equally at risk?

A team of researchers from the U.S. and China re-examined those questions in a series of studies in rats. In findings released Wednesday, they reported that certain intestinal bacteria play a crucial role in how the body handles melamine.

The intestines of all mammals teem with different species of bacteria that perform different jobs. To see if one of those activities involves processing melamine, researchers from the University of North Carolina at Greensboro and Shanghai Jiao Tong University gave lab rats antibiotics to kill off some of the germs — and then fed them melamine.

The antibiotic-treated rats excreted twice as much of the melamine as rats that didn't get antibiotics, and they experienced fewer kidney stones and other damage.

A closer look identified why: A particular intestinal germ — named Klebsiella terrigena — was metabolizing melamine to create a more toxic byproduct, the team reported in the journal Science Translational Medicine.

Previous studies have estimated that fewer than 1 percent of healthy people harbor that bacteria species. A similar fraction of melamine-exposed children in China got sick, the researchers wrote. But proving that link would require studying stool samples preserved from affected children, they cautioned.

Still, the research is pretty strong, said microbiologist Jack Gilbert of the University of Chicago and Argonne National Laboratory, who wasn't involved in the new study.

More importantly, "this paper adds to a growing body of evidence which suggests that microbes in the body play a significant role in our response to toxicity and in our health in general," Gilbert said.

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Officer Dies After Dorner Shootout; Cabin on Fire

The remote California mountain cabin in which fugitive ex-cop Christopher Dorner has barricaded himself in tense standoff with police is on fire, following a shootout with police in which one officer was killed and another wounded.

Once the fire started, a single shot was heard from inside the cabin and then flames and a large column of black smoke were seen rising above the snow-covered trees near Big Bear, Calif., ABC station KABC-TV in Los Angeles reported.

Dorner is a former Navy marksman and Los Angeles Police Department officer charged with murdering a police officer and suspected in the deaths of two other people, including the daughter of a former LAPD captain, earlier this month.

Dozens of local, state and federal authorities are at the scene in the San Bernardino Mountains, and have the the cabin surrounded. Dorner has sworn to kill police and their family members in a manifesto discovered online last week.

FULL COVERAGE: Christopher Dorner Manhunt

The search for Dorner, one of the largest manhunts in recent memory, took a turn this afternoon when police received a call that a suspect resembling Dorner had broken into a home in the Big Bear area, taken hostages and stolen a car.

Police said the former cop, believed to be heavily armed and extremely dangerous, took two women hostage before stealing a car just around 12:20 p.m. PT, police said.

Christopher Dorner Manhunt: Police Exchange Fire With Possible Suspect Watch Video

Fugitive Ex-Cop Believed Barricaded in Cabin, California Cops Say Watch Video

The two hostages, who were tied up by Dorner but later escaped, were evaluated by paramedics and were determined to be uninjured.

Officials say Dorner crashed the stolen vehicle and fled on foot to the cabin where he barricaded himself and exchanged fire with deputies from the San Bernardino Sheriff's Office and state Fish and Game officers.

Two deputies were wounded in the firefight and airlifted to a nearby hospital, where one died, police said. The second deputy was in surgery and was expected to survive, police said.

PHOTOS: Former LAPD Officer Suspected in Shootings

Police have sealed all roads going into the area and imposed a no-fly zone above the cabin, nestled in a wooded area that has received several inches of snow in recent days.

Four Big Bear area schools were briefly placed on lockdown.

The San Bernardino County Sheriff's Department stopped all traffic leaving the area and thoroughly searched vehicles, as SWAT team and tactical units could be seen driving toward the cabin, their sirens blaring.

Authorities say they believe Dorner may be watching reports of the standoff and have asked media not to broadcast images of police surrounding the cabin.

"If he's watching this, the message ... is: Enough is enough. It's time to turn yourself in. It's time to stop the bloodshed. It's time to let this event and let this incident be over," said Los Angeles Police Department spokesman Andy Smith, told reporters at a press conference.

Dorner faces capital murder charges that involve the killing of Riverside police officer Michael Crain, who was gunned down in an ambush last Thursday.

Since then a massive manhunt has been under way, focused primarily in the San Bernardino Mountains, but extending to neighboring states and as far away as Mexico.

A capital murder charge could result in the death penalty if Dorner is captured alive and convicted. Crain was married with two children, aged 10 and 4.

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North Korean nuclear test draws anger, including from China

SEOUL (Reuters) - North Korea conducted its third nuclear test on Tuesday in defiance of U.N. resolutions, drawing condemnation from around the world, including from its only major ally, China, which summoned the North Korean ambassador to protest.

Pyongyang said the test was an act of self-defense against "U.S. hostility" and threatened stronger steps if necessary.

The test puts pressure on U.S. President Barack Obama on the day of his State of the Union speech and also puts China in a tight spot, since it comes in defiance of Beijing's admonishments to North Korea to avoid escalating tensions.

The U.N. Security Council held an emergency meeting at which its members, including China, "strongly condemned" the test and vowed to start work on appropriate measures in response, the president of the council said.

North Korean leader Kim Jong-un, the third of his line to rule the country, has presided over two long-range rocket launches and a nuclear test during his first year in power, pursuing policies that have propelled his impoverished and malnourished country closer to becoming a nuclear weapons power.

North Korea said the test had "greater explosive force" than those it conducted in 2006 and 2009. Its KCNA news agency said it had used a "miniaturized" and lighter nuclear device, indicating it had again used plutonium, which is suitable for use as a missile warhead.

China, which has shown signs of increasing exasperation with the recent bellicose tone of its reclusive neighbor, summoned the North Korean ambassador in Beijing and protested sternly, the Foreign Ministry said.

Foreign Minister Yang Jiechi said China was "strongly dissatisfied and resolutely opposed" to the test and urged North Korea to "stop any rhetoric or acts that could worsen situations and return to the right course of dialogue and consultation as soon as possible".

Analysts said the test was a major embarrassment to China, which is a permanent member of the Security Council and North Korea's sole major economic and diplomatic ally.

Obama called the test a "highly provocative act" that hurt regional stability.

"The danger posed by North Korea's threatening activities warrants further swift and credible action by the international community. The United States will also continue to take steps necessary to defend ourselves and our allies," Obama said.

U.S. Ambassador to the United Nations Susan Rice said Washington and its allies intended to "augment the sanctions regime" already in place due to Pyongyang's previous atomic tests. North Korea is already one of the most heavily sanctioned states in the world and has few external economic links that can be targeted.

Japanese Prime Minister Shinzo Abe said the test was a "grave threat" that could not be tolerated.

Russian Foreign Minister Sergei Lavrov urged North Korea to abandon its nuclear arms program and return to talks. NATO condemned the test as an "irresponsible act."

South Korea, still technically at war with North Korea after a 1950-53 civil war ended in a mere truce, also denounced the test. Obama spoke to South Korean President Lee Myung-bak on Tuesday and told him the United States "remains steadfast in its defense commitments" to Korea, the White House said.

MAXIMUM RESTRAINT

North Korea's Foreign Ministry said the test was "only the first response we took with maximum restraint".

"If the United States continues to come out with hostility and complicates the situation, we will be forced to take stronger, second and third responses in consecutive steps," it said in a statement carried by the official KCNA news agency.

North Korea - which gave the U.S. State Department advance warning of the test - often threatens the United States and its "puppet", South Korea, with destruction in colorful terms.

North Korea told the U.N. disarmament forum in Geneva that it would never bow to resolutions on its nuclear program and that prospects were "gloomy" for the denuclearization of the divided Korean peninsula because of a "hostile" U.S. policy.

Suzanne DiMaggio, an analyst at the Asia Society in New York, said North Korea had embarrassed China with the test. "China's inability to dissuade North Korea from carrying through with this third nuclear test reveals Beijing's limited influence over Pyongyang's actions in unusually stark terms," she said.

Mark Fitzpatrick of the International Institute for Strategic Studies think tank, said: "The test is hugely insulting to China, which now can be expected to follow through with threats to impose sanctions."

The magnitude of the explosion was roughly twice that of the 2009 test, according to the Vienna-based Comprehensive Nuclear-Test Ban Treaty Organization. The U.S. Geological Survey said that a seismic event measuring 5.1 magnitude had occurred.

U.S. intelligence agencies were analyzing the event and found that North Korea probably conducted an underground nuclear explosion with a yield of "approximately several kilotons", the Office of the Director of National Intelligence said.

Nuclear experts have described Pyongyang's previous two tests as puny by international standards. The yield of the 2006 test has been estimated at less than 1 kiloton (1,000 tons of TNT equivalent) and the second at some 2-7 kilotons, compared with 20 kilotons for a Nagasaki-type bomb.

Initial indications are that the test involved the latest version of a plutonium-based prototype weapon, according to one current and one former U.S. national security official. Both previous tests involved plutonium. If it turns out the test was of a new uranium-based weapon, it would show that North Korea has made more progress on uranium enrichment than previously thought.

The United States uses WC-135 Constant Phoenix "sniffer" aircraft to collect samples to identify nuclear explosions. These would need to be deployed quickly to detect whether highly enriched uranium rather than plutonium was used because uranium decays to undetectable levels within a matter of days. Plutonium takes much longer to decay.

North Korea trumpeted news of the test on its state television channel to patriotic music against a backdrop of its national flag.

"It was confirmed that the nuclear test that was carried out at a high level in a safe and perfect manner using a miniaturized and lighter nuclear device with greater explosive force than previously did not pose any negative impact on the surrounding ecological environment," KCNA said.

North Korea linked the test to its technical prowess in launching a long-range rocket in December, a move that triggered the U.N. sanctions, backed by China, that Pyongyang said prompted it to take Tuesday's action.

The North's ultimate aim, Washington believes, is to design an intercontinental ballistic missile capable of carrying a nuclear warhead that could hit the United States. North Korea says the program is aimed at putting satellites in space.

Despite its three nuclear tests and long-range rocket tests, North Korea is not believed to be close to manufacturing a nuclear missile capable of hitting the United States.

It used plutonium in previous nuclear tests and before Tuesday there had been speculation that it would use highly enriched uranium so as to conserve its plutonium stocks, as testing eats into its limited supply of materials to construct a nuclear bomb.

"VICIOUS CYCLE"

When Kim Jong-un, who is 30, took power after his father's death in December 2011, there were hopes that he would bring reforms and end Kim Jong-il's "military first" policies.

Instead, North Korea, whose economy is smaller than it was 20 years ago and where a third of children are believed to be malnourished, appears to be trapped in a cycle of sanctions followed by further provocations.

"The more North Korea shoots missiles, launches satellites or conducts nuclear tests, the more the U.N. Security Council will impose new and more severe sanctions," said Shen Dingli, a professor at Shanghai's Fudan University. "It is an endless, vicious cycle."

Options for the international community appear to be in short supply. Diplomats at the United Nations said negotiations on new sanctions could take weeks since China is likely to resist tough new measures for fear they could lead to further retaliation by the North Korean leadership.

Beijing has also been concerned that tougher sanctions could further weaken North Korea's economy and prompt a flood of refugees into China.

Tuesday's action appeared to have been timed for the run-up to February 16 anniversary celebrations of Kim Jong-il's birthday, as well as to achieve maximum international attention.

Significantly, the test comes at a time of political transition in China, Japan and South Korea, and as Obama begins his second term. The U.S. president will likely have to tweak his State of the Union address due to be given on Tuesday.

Japanese Prime Minister Shinzo Abe is bedding down a new government and South Korea's new president, Park Geun-hye, is preparing to take office on February 25.

China too is in the midst of a once-in-a-decade leadership transition to Xi Jinping, who takes office in March. Both Abe and Xi are staunch nationalists.

The longer-term game plan from Pyongyang may be to restart international talks aimed at winning food and financial aid. China urged it to return to the stalled "six-party" talks on its nuclear program, hosted by China and including the two Koreas, the United States, Japan and Russia.

Its puny economy and small diplomatic reach mean that North Korea struggles to win attention on the global stage - other than through nuclear tests and attacks on South Korea, the last of which was made in 2010.

"Now the next step for North Korea will be to offer talks... - any form to start up discussion again to bring things to their advantage," predicted Jeung Young-tae, senior research fellow at the Korea Institute for National Unification in Seoul.

(Additional reporting by Jack Kim, Christine Kim and Jumin Park in SEOUL; Linda Sieg in TOKYO; Louis Charbonneau and Michelle Nichols at the UNITED NATIONS; Fredrik Dahl in VIENNA; Michael Martina and Chen Aizhu in BEIJING; Mette Fraende in COPENHAGEN; Adrian Croft, Charlie Dunmore and Justyna Pawlak in BRUSSELS; Mark Hosenball, Paul Eckert, Roberta Rampton, Tabassum Zakaria and Jeff Mason in WASHINGTON; Editing by Nick Macfie, Claudia Parsons and David Brunnstrom)

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Peru archeologists find ancient temple

LIMA: Peruvian archaeologists have discovered a temple believed to be about 5,000 years old at the ancient archaeological site of El Paraiso in a valley just north of Lima, the Culture Ministry said Tuesday.

If the date is confirmed, it would be among the oldest sites in the world, comparable to the ancient city of Caral, a coastal city some 200 kilometres (125 miles) to the north.

The discovery, dubbed the Temple of Fire, was found in one of the wings of El Paraiso's main pyramid. It includes a hearth that experts believe was used to burn ceremonial offerings.

"The smoke allowed the priests to connect with the gods," said Marco Guillen, who led the team of researchers who made the find.

Archaeologists found the hearth in mid-January as they were carrying out conservation work at a set of 4,000-year-old ruins known as El Paraiso, located some 40 kilometers northeast of Lima in the Chillon River Valley.

The discovery shows "that the Lima region was a focus of civilizations in the Andean territory," Deputy Culture Minister Rafael Varon told reporters.

Archaeologists believe the ancient coastal civilisations raised crops including cotton, which they traded with coastal fishermen for food.

El Paraiso, spread across 50 hectares (125 acres), has 10 buildings and is one of the largest ancient sites in central Peru.

-AFP/gn

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Haryana Roadways staff stir may hit 3500 govt buses too

CHANDIGARH: The call for the roadways employees' strike may hit the government transport services in Haryana on Wednesday.

All Haryana Roadways Workers Joint Action Committee, an umbrella body of two trade unions, has given the call for the strike to press the workers' demand of regularization of contractual staff and stop the process of giving 3519 permits to private bus operators in Haryana.

A senior leader of the committee, Dalbir Kirmara told the TOI that the committee has appealed to roadways employees, including drivers and conductors of 3500 government buses to remain off the road on Wednesday.

However, the state government has urged the employees not to resort to strike claiming that government has already accepted most of their demands and the remaining were being examined.

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Study questions kidney cancer treatment in elderly

In a stunning example of when treatment might be worse than the disease, a large review of Medicare records finds that older people with small kidney tumors were much less likely to die over the next five years if doctors monitored them instead of operating right away.

Even though nearly all of these tumors turned out to be cancer, they rarely proved fatal. And surgery roughly doubled patients' risk of developing heart problems or dying of other causes, doctors found.

After five years, 24 percent of those who had surgery had died, compared to only 13 percent of those who chose monitoring. Just 3 percent of people in each group died of kidney cancer.

The study only involved people 66 and older, but half of all kidney cancers occur in this age group. Younger people with longer life expectancies should still be offered surgery, doctors stressed.

The study also was observational — not an experiment where some people were given surgery and others were monitored, so it cannot prove which approach is best. Yet it offers a real-world look at how more than 7,000 Medicare patients with kidney tumors fared. Surgery is the standard treatment now.

"I think it should change care" and that older patients should be told "that they don't necessarily need to have the kidney tumor removed," said Dr. William Huang of New York University Langone Medical Center. "If the treatment doesn't improve cancer outcomes, then we should consider leaving them alone."

He led the study and will give results at a medical meeting in Orlando, Fla., later this week. The research was discussed Tuesday in a telephone news conference sponsored by the American Society of Clinical Oncology and two other cancer groups.

In the United States, about 65,000 new cases of kidney cancer and 13,700 deaths from the disease are expected this year. Two-thirds of cases are diagnosed at the local stage, when five-year survival is more than 90 percent.

However, most kidney tumors these days are found not because they cause symptoms, but are spotted by accident when people are having an X-ray or other imaging test for something else, like back trouble or chest pain.

Cancer experts increasingly question the need to treat certain slow-growing cancers that are not causing symptoms — prostate cancer in particular. Researchers wanted to know how life-threatening small kidney tumors were, especially in older people most likely to suffer complications from surgery.

They used federal cancer registries and Medicare records from 2000 to 2007 to find 8,317 people 66 and older with kidney tumors less than 1.5 inches wide.

Cancer was confirmed in 7,148 of them. About three-quarters of them had surgery and the rest chose to be monitored with periodic imaging tests.

After five years, 1,536 had died, including 191 of kidney cancer. For every 100 patients who chose monitoring, 11 more were alive at the five-year mark compared to the surgery group. Only 6 percent of those who chose monitoring eventually had surgery.

Furthermore, 27 percent of the surgery group but only 13 percent of the monitoring group developed a cardiovascular problem such as a heart attack, heart disease or stroke. These problems were more likely if doctors removed the entire kidney instead of just a part of it.

The results may help doctors persuade more patients to give monitoring a chance, said a cancer specialist with no role in the research, Dr. Bruce Roth of Washington University in St. Louis.

Some patients with any abnormality "can't sleep at night until something's done about it," he said. Doctors need to say, "We're not sticking our head in the sand, we're going to follow this" and can operate if it gets worse.

One of Huang's patients — 81-year-old Rhona Landorf, who lives in New York City — needed little persuasion.

"I was very happy not to have to be operated on," she said. "He said it's very slow growing and that having an operation would be worse for me than the cancer."

Landorf said her father had been a doctor, and she trusts her doctors' advice. Does she think about her tumor? "Not at all," she said.

___

Online:

Kidney cancer info: http://www.cancer.net/cancer-types/kidney-cancer

and http://www.cancer.gov/cancertopics/types/kidney

Study: http://gucasym.org

___

Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP

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Who's Next? A Look at Likely Successors to Benedict

With 1 billion Catholics worldwide, the face of the church is changing.

It's something the cardinal electors may keep in mind when the conclave to elect a new pontiff begins in late March, said Matthew Bunson, general editor of the Catholic Almanac and author of "We Have a Pope! Benedict XVI."

RELATED: Pope Benedict XVI Resigns: The Statement

The 117 cardinals who are eligible to vote for the new pontiff hail from approximately 50 different countries, and they almost always elect one of their own.

Joseph Ratzinger, an intellectual and respected cardinal from Germany, was the frontrunner for the papacy in 2005, Bunson said. When elected, he became Pope Benedict XVI.

This year, there are no strong favorites.

"The door, in a way, is very much open," Bunson said.

FULL COVERAGE: Pope Benedict XVI Resignation

Here's a quick look at some of the possible picks for pope:

Angelo Cardinal Scola, 71, Italy

Scola was named the Archbishop of Milan in 2011, a prominent post in the Roman Catholic church.

"If we had to pick a frontrunner, it's him," Bunson said. "He first is a brilliant theologian and has the intellectual heft to be pope, which is crucial. He has the clear favor of Pope Benedict.

Milan and Venice together have produced five popes in the past century.

Scola is also committed to promoting an understanding across faiths.

He started the Oasis Foundation in 2004, which helps bridge a dialogue between Christians and Muslims.

Helen Alvaré, a professor of law at George Mason University and an advisor to Pope Benedict XVI's Pontifical Council for the Laity, agreed that Scola will be considered papabili -- an Italian word for someone highly qualified for the papacy.

"It would not be surprise me if a Scola, or another great European mind also was determined to be what was needed for the times," she said.

Marc Cardinal Ouellet, 68, Canada

The former Archbishop of Quebec, who now heads the Congregation of Bishops, has a deep knowledge of the global workings of the church, Bunson said.

"He has had a major role in the appointment of the church's leaders around the world," Bunson said.

And he points out that at 68 years old, Ouellet has age on his side.

Ouellet is someone who could have "worldwide reach," Alvaré said.

"The man who is chosen for the position he has is someone who is understood to have the presence and the future of the church in mind," she said.

Peter Cardinal Turkson, 64, Ghana

Turkson, who hails from Ghana, may be in the running.

He is currently the president of the Pontifical Council for Justice and Peace, a post he was appointed to by Pope Benedict XVI in 2009.

The job has sent Turkson, who speaks six languages, around the world to handle mediations.

"The fact that an African cardinal is a candidate to be elected pope is the statement to the diversity of the church and the remarkable growth around the world," Bunson said.

Turkson discussed the possible of a black pope at a press conference in 2009, following the U.S. presidential election.

"And if by divine providence -- because the church belongs to God -- if God would wish to see a black man also as Pope, thanks be to God," he said.

Francis Cardinal Arinze, from Nigeria, has also been discussed as a potential pope.

Leonardo Cardinal Sandri, 69, Argentina

With a large center of Catholic faithful in Latin America, Sandri could become the first pope from the region.

The 69-year-old, who was born in Argentina to Italian parents, served as a chief of staff in the Vatican, often reading public message when Pope John Paul II was in declining health.

It was Sandri who announced the passing of the pontiff in St. Peter's Square on April 2, 2005.

"He's well-liked around the world," Bunson said.

He currently serves on the Congregation for the Oriental Churches, acting as a liason with Eastern European Catholic churches.

Sandri is fluent in English, Spanish, Italian, German and French.

Angelo Cardinal Bagnasco, 70, Italy

The Archbishop of Genoa has a "reputation for intellectual heft," Bunson said.

Bagnasco, two-time president of the Italian Bishops Conference, has a history of taking a strong stance on church doctrine.

In 2007, he was the subject of death threats after he led a campaign against proposed Italian legislation to grant some legal rights to unmarried couples, including people in same-sex relationships.

Italians form the largest voting block in the College of Cardinals, with 25 percent of the seats, and could help propel Bagnasco into the papacy.

Tarsicio Cardinal Bertone, 78, Italy

The current Cardinal Secretary of State is a strong candidate if the Holy Spirit wants another great European mind at the helm of the church, Alvaré said.

Bertone runs the day-to-day business of the Roman Curia, the Vatican's government.

He has reportedly been criticized by Vatican officials for his handling of issues ranging from sexual abuse in the church to Vatican finances.

In an open letter last year, Pope Benedict XVI acknowledged the in-fighting and pledged his support for his secretary of state.

"I've noted with regret the unjust criticism directed at your person," the pope wrote. "I intend to reaffirm my pledge of personal faith in you."

Although he's held in high regard by the pope, Bunson believes Bertone's age will keep him from the papacy.

"His age is against him," he said, pointing out that Bertone is the same age as his boss when he was elected.

Timothy Cardinal Dolan, 63, New York

While the thought of an American pope has long seemed impossible, Cardinal Dolan should not be ruled out, Alvaré said.

"History is changing," she said. "We've been at this a while here in the states, [although] not anywhere as long as Europe."

Dolan, an affable cardinal well-known by Catholics in the U.S. and abroad, "has been grappling with some of the leading questions that face the church for the future," Alvaré said.

In September 2012, along with comedian Stephen Colbert, he co-led a discussion on faith and humor at Fordham University.

"If I am elected pope, which is probably the greatest gag all evening, I'll be Stephen III," he told the crowd of students.

Despite Dolan's good standing, Bunson said he has some doubts.

"It strikes me as unlikely, simply because we are the world's last superpower," he said of the U.S. "So I think that might factor in."

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Pope's sudden resignation sends shockwaves through Church

VATICAN CITY (Reuters) - Pope Benedict stunned the Roman Catholic Church on Monday when he announced he would stand down, the first pope to do so in 700 years, saying he no longer had the mental and physical strength to carry on.

Church officials tried to relay a climate of calm confidence in the running of a 2,000-year-old institution, but the decision could lead to uncertainty in a Church already besieged by scandal for covering up sexual abuse of children by priests.

The soft-spoken German, who always maintained that he never wanted to be pope, was an uncompromising conservative on social and theological issues, fighting what he regarded as the increasing secularization of society.

It remains to be seen whether his successor will continue such battles or do more to bend with the times.

Despite his firm opposition to tolerance of homosexual acts, his eight year reign saw gay marriage accepted in many countries. He has staunchly resisted allowing women to be ordained as priests, and opposed embryonic stem cell research, although he retreated slightly from the position that condoms could never be used to fight AIDS.

He repeatedly apologized for the Church's failure to root out child abuse by priests, but critics said he did too little and the efforts failed to stop a rapid decline in Church attendance in the West, especially in his native Europe.

In addition to child sexual abuse crises, his papacy saw the Church rocked by Muslim anger after he compared Islam to violence. Jews were upset over rehabilitation of a Holocaust denier. During a scandal over the Church's business dealings, his butler was accused of leaking his private papers.

In an announcement read to cardinals in Latin, the universal language of the Church, the 85-year-old said: "Well aware of the seriousness of this act, with full freedom I declare that I renounce the ministry of Bishop of Rome, Successor of St Peter ...

"As from 28 February 2013, at 20:00 hours (1900 GMT) the See of Rome, the See of St. Peter will be vacant and a conclave to elect the new Supreme Pontiff will have to be convoked by those whose competence it is."

POPE DOESN'T FEAR SCHISM

Benedict is expected to go into isolation for at least a while after his resignation. Vatican spokesman Father Federico Lombardi said Benedict did not intend to influence the decision of the cardinals in a secret conclave to elect a successor.

A new leader of the world's 1.2 billion Roman Catholics could be elected as soon as Palm Sunday, on March 24, and be ready to take over by Easter a week later, Lombardi said.

Several popes in the past, including Benedict's predecessor John Paul, have refrained from stepping down over their health, because of the division that could be caused by having an "ex-pope" and a reigning pope alive at the same time.

Lombardi said the pope did not fear a possible "schism", with Catholics owing allegiances to a past and present pope in case of differences on Church teachings.

He indicated the complex machinery of the process to elect a new pope would move quickly because the Vatican would not have to wait until after the elaborate funeral services for a pope.

It is not clear if Benedict will have a public life after he resigns. Lombardi said Benedict would first go to the papal summer residence south of Rome and then move into a cloistered convent inside the Vatican walls.

The resignation means that cardinals from around the world will begin arriving in Rome in March and after preliminary meetings, lock themselves in a secret conclave and elect the new pope from among themselves in votes in the Sistine Chapel.

There has been growing pressure on the Church for it to choose a pope from the developing world to better reflect where most Catholics live and where the Church is growing.

"It could be time for a black pope, or a yellow one, or a red one, or a Latin American," said Guatemala's Archbishop Oscar Julio Vian Morales.

The cardinals may also want a younger man. John Paul was 58 when he was elected in 1978. Benedict was 20 years older.

"We have had two intellectuals in a row, two academics, perhaps it is time for a diplomat," said Father Tom Reese, senior fellow at the Woodstock Theological Center at Georgetown University. "Rather than electing the smartest man in the room, they should elect the man who will listen to all the other smart people in the Church."

Liberals have already begun calling for a pope that would be more open to reform.

"The current system remains an 'old boy's club' and does not allow for women's voices to participate in the decision of the next leader of our Church," said the Women's Ordination Conference, a group that wants women to be able to be priests.

"GREAT COURAGE"

The last pope to resign willingly was Celestine V in 1294 after reigning for only five months, his resignation was known as "the great refusal" and was condemned by the poet Dante in the "Divine Comedy". Gregory XII reluctantly abdicated in 1415 to end a dispute with a rival claimant to the papacy.

Lombardi said Benedict's stepping aside showed "great courage". He ruled out any specific illness or depression and said the decision was made in the last few months "without outside pressure". But the decision was not without controversy.

"This is disconcerting, he is leaving his flock," said Alessandra Mussolini, a parliamentarian who is granddaughter of Italy's wartime dictator. "The pope is not any man. He is the vicar of Christ. He should stay on to the end, go ahead and bear his cross to the end. This is a huge sign of world destabilization that will weaken the Church."

Cardinal Stanislaw Dziwisz, secretary to the late Pope John Paul, said the former pope had stayed on despite failing health for the last decade of his life as he believed "you cannot come down from the cross."

While the pope had slowed down recently - he started using a cane and a wheeled platform to take him up the long aisle in St Peter's Square - he had given no hint recently that he was considering such a dramatic decision.

Elected in 2005 to succeed the enormously popular John Paul, Benedict never appeared to feel comfortable in the job.

"MIND AND BODY"

In his announcement, the pope told the cardinals that in order to govern "... both strength of mind and body are necessary, strength which in the last few months, has deteriorated in me to the extent that I have had to recognize my incapacity to adequately fulfill the ministry entrusted to me."

Before he was elected pope, the former Cardinal Joseph Ratzinger was known as "God's rottweiler" for his stern stand on theological issues. After a few months, he showed a milder side but he never drew the kind of adulation that had marked the 27-year papacy of his predecessor John Paul.

U.S. President Barack Obama extended prayers to Benedict and best wishes to those who would choose his successor.

German Chancellor Angela Merkel said the pope's decision must be respected if he feels he is too weak to carry out his duties. British Prime Minister David Cameron said: "He will be missed as a spiritual leader to millions."

The Archbishop of Canterbury, leader of the worldwide Anglican communion, said he had learned of the pope's decision with a heavy heart but complete understanding.

CHEERS AND SCANDAL

Elected to the papacy on April 19, 2005, Benedict ruled over a slower-paced, more cerebral and less impulsive Vatican.

But while conservatives cheered him for trying to reaffirm traditional Catholic identity, his critics accused him of turning back the clock on reforms by nearly half a century and hurting dialogue with Muslims, Jews and other Christians.

After appearing uncomfortable in the limelight at the start, he began feeling at home with his new job and showed that he intended to be pope in his way.

Despite great reverence for his charismatic, globe-trotting predecessor -- whom he put on the fast track to sainthood and whom he beatified in 2011 -- aides said he was determined not to change his quiet manner to imitate John Paul's style.

A quiet, professorial type who relaxed by playing the piano, he showed the gentle side of a man who was the Vatican's chief doctrinal enforcer for nearly a quarter of a century.

The first German pope for some 1,000 years and the second non-Italian in a row, he traveled regularly, making about four foreign trips a year, but never managed to draw the oceanic crowds of his predecessor.

The child abuse scandals hounded most of his papacy. He ordered an official inquiry into abuse in Ireland, which led to the resignation of several bishops.

Scandal from a source much closer to home hit in 2012 when the pontiff's butler, responsible for dressing him and bringing him meals, was found to be the source of leaked documents alleging corruption in the Vatican's business dealings.

Benedict confronted his own country's past when he visited the Nazi death camp at Auschwitz. Calling himself "a son of Germany", he prayed and asked why God was silent when 1.5 million victims, most of them Jews, were killed there.

Ratzinger served in the Hitler Youth during World War Two when membership was compulsory. He was never a member of the Nazi party and his family opposed Adolf Hitler's regime.

(Additional reporting by James Mackenzie, Barry Moody, Cristiano Corvino, Alexandra Hudson in Berlin, and Dagamara Leszkowixa in Poland; Editing by Peter Graff)

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American Express card users can shop at Twitter

SAN FRANCISCO: American Express began letting users of its payment cards make purchases with messages fired off at Twitter as the popular social network dabbles with making money from e-commerce.

American Express announced that members who synchronize their cards with Twitter can take advantage of offers "tweeted" by the financial services company.

American Express will promote products in messages fired off at Twitter. Card holders buy items by tweeting indicated hashtags, with their accounts being charged accordingly.

Depending on the offers, products will be shipped to buyers or picked up in shops.

"We're leveraging our unique technology and closed-loop network to introduce a seamless solution that redefines what's possible in the world of social commerce," said American Express senior vice president Leslie Berland.

"We know there is significant power in combining our assets with Twitter's platform."

American Express said cardholders will be able to buy Sony, Amazon.com, Xbox 360 or Urban Zen products in tweets by using special hashtags, or words preceded by the "#" symbol.

Twitter and American Express have worked together in the past with alliances that let cardholders take advantage of discounts offered in coupons tweeted by merchants.

- AFP/ck

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Kumbh stampede: Minister refutes callousness charge

NEW DELHI: The railways were caught off guard on Sunday after the Allahabad administration diverted a deluge of pilgrims towards the station complex which ultimately caused the stampede, sources said.

This happened all of a sudden as thousands of pilgrims poured in through the Civil Lines between 5pm and 6pm. It wasn't part of the plan shared with them and the railway authorities were stumped. In no time, the station complex was overflowing, platforms were packed, the foot overbridge and circulation area were teeming with jostling pilgrims.

A day after the stampede, a blame game began between the railways and the state government. The railways insisted they were kept in the dark on crowd management plans, but the administration blamed it on a lathicharge at the station. Railway minister Pawan Bansal, in Allahabad on Monday, strongly defended his department saying the stampede happened because of the rush and that all arrangements were in place. He denied a lathicharge triggered the panic.

Despite the railway effort to shift blame, one thing seems clear: It failed to estimate the likely crowd at the station. Not enough security men were at the station. Unlike CRPF, BSF and RAF, trained in crowd control, the Government Railway Police isn't . Allahabad can handle a maximum of 40,000 commuters at a time and it's now being asked why railway authorities allowed nearly 3lakh people to descend on its premises at a go. "Piligrims could have been diverted to smaller halts and informed about train movements over the public address system," Shiv Gopal Mishra, general secretary of the All India Railwaymen Federation said. Mishra was in Allahabad on Sunday.

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