UN warns risk of hepatitis E in S. Sudan grows

GENEVA (AP) — The United Nations says an outbreak of hepatitis E has killed 111 refugees in camps in South Sudan since July, and has become endemic in the region.

U.N. refugee agency spokesman Adrian Edwards says the influx of people to the camps from neighboring Sudan is believed to be one of the factors in the rapid spread of the contagious, life-threatening inflammatory viral disease of the liver.

Edwards said Friday that the camps have been hit by 6,017 cases of hepatitis E, which is spread through contaminated food and water.

He says the largest number of cases and suspected cases is in the Yusuf Batil camp in Upper Nile state, which houses 37,229 refugees fleeing fighting between rebels and the Sudanese government.

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Exclusive: North Korea tells China of preparations for fresh nuclear test - source

BEIJING (Reuters) - North Korea has told its key ally, China, that it is prepared to stage one or even two more nuclear tests this year in an effort to force the United States into diplomatic talks, said a source with direct knowledge of the message.

Further tests could also be accompanied this year by another rocket launch, said the source, who has direct access to the top levels of government in both Beijing and Pyongyang.

North Korea conducted its third nuclear test on Tuesday, drawing global condemnation and a stern warning from the United States that it was a threat and a provocation.

"It's all ready. A fourth and fifth nuclear test and a rocket launch could be conducted soon, possibly this year," the source said, adding that the fourth nuclear test would be much larger than the third, at an equivalent of 10 kilotons of TNT.

The tests will be undertaken, the source said, unless Washington holds talks with North Korea and abandons its policy of what Pyongyang sees as attempts at regime change.

North Korea also reiterated its long-standing desire for the United States to sign a final peace agreement with it and establish diplomatic relations, he said. North Korea remains technically at war with both the United States and South Korea after the Korean war ended in 1953 with a truce.

In Washington, U.S. State Department spokeswoman Victoria Nuland urged North Korea to "refrain from additional provocative actions that would violate its international obligations" under three different sets of U.N. Security Council resolutions that prohibit nuclear and missile tests.

North Korea "is not going to achieve anything in terms of the health, welfare, safety, future of its own people by these kinds of continued provocative actions. It's just going to lead to more isolation," Nuland told reporters.

The Pentagon also weighed in, calling North Korea's missile and nuclear programs "a threat to U.S. national security and to international peace and security."

"The United States remains vigilant in the face of North Korean provocations and steadfast in our defense commitments to allies in the region," said Pentagon spokeswoman Major Catherine Wilkinson.

Initial estimates of this week's test from South Korea's military put its yield at the equivalent of 6-7 kilotons, although a final assessment of yield and what material was used in the explosion may be weeks away.

North Korea's latest test, its third since 2006, prompted warnings from Washington and others that more sanctions would be imposed on the isolated state. The U.N. Security Council has only just tightened sanctions on Pyongyang after it launched a long-range rocket in December.

Pyongyang is banned under U.N. sanctions from developing missile or nuclear technology after its 2006 and 2009 nuclear tests.

North Korea worked to ready its nuclear test site, about 100 km (60 miles) from its border with China, throughout last year, according to commercially available satellite imagery. The images show that it may have already prepared for at least one more test, beyond Tuesday's subterranean explosion.

"Based on satellite imagery that showed there were the same activities in two tunnels, they have one tunnel left after the latest test," said Kune Y. Suh, a nuclear engineering professor at Seoul National University in South Korea.

Analysis of satellite imagery released on Friday by specialist North Korea website 38North showed activity at a rocket site that appeared to indicate it was being prepared for a launch (http://38north.org/2013/02/tonghae021413/).

NORTH 'NOT AFRAID' OF SANCTIONS

President Barack Obama pledged after this week's nuclear test "to lead the world in taking firm action in response to these threats" and diplomats at the U.N. Security Council have already started discussing potential new sanctions.

North Korea has said the test was a reaction to "U.S. hostility" following its December rocket launch. Critics say the rocket launch was aimed at developing technology for an intercontinental ballistic missile.

"(North) Korea is not afraid of (further) sanctions," the source said. "It is confident agricultural and economic reforms will boost grain harvests this year, reducing its food reliance on China."

North Korea's isolated and small economy has few links with the outside world apart from China, its major trading partner and sole influential diplomatic ally.

China signed up for international sanctions against North Korea after the 2006 and 2009 nuclear tests and for a U.N. Security Council resolution passed in January to condemn the latest rocket launch. However, Beijing has stopped short of abandoning all support for Pyongyang.

Sanctions have so far not discouraged North Korea from pursuing its nuclear ambitions.

"It is like watching the same movie over and over again," said Lee Woo-young, a professor at Seoul's University of North Korean Studies. "The idea that stronger sanctions make North Korea stop developing nuclear programs isn't effective in my view."

The source with ties to Beijing and Pyongyang said China would again support U.N. sanctions. He declined to comment on what level of sanctions Beijing would be willing to endorse.

"When China supported U.N. sanctions ... (North) Korea angrily called China a puppet of the United States," he said. "There will be new sanctions which will be harsh. China is likely to agree to it," he said, without elaborating.

He said however that Beijing would not cut food and fuel supplies to North Korea, a measure it reportedly took after a previous nuclear test.

He said North Korea's actions were a distraction for China's leadership, which was concerned that the escalations could inflame public opinion in China and hasten military build-ups in the region.

The source said he saw little room for compromise under North Korea's youthful new leader, Kim Jong-un. The third Kim to rule North Korea is just 30 years old and took over from his father in December 2011.

He appears to have followed his father, Kim Jong-il, in the "military first" strategy that has pushed North Korea ever closer to a workable nuclear missile at the expense of economic development.

"He is much tougher than his father," the source said.

(Additional reporting by Arshad Mohammed and Phillip Stewart in WASHINGTON; Writing by David Chance; Editing by Raju Gopalakrishnan, David Brunnstrom and Jackie Frank)

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Alleged cop killer died from single shot to head

LOS ANGELES: Alleged US cop killer Christopher Dorner died from a single gunshot wound to the head that appeared to be self-inflicted, a coroner said.

The doctor who examined the body concluded that "the cause of death was a single gunshot wound to the head," said San Bernardino County coroner Kevin Lacy, giving details from the results of a six-hour autopsy.

"We are not yet able to speak about the manner of death and tell you whether or not it was the result of a self-inflicted wound or another round," he told a press conference.

But he said, "while we are still assembling the reports and putting it together, the implication seems to be that the wound that took Christopher Dorner's life was self-inflicted."

The ex-Los Angeles Police Department (LAPD) cop went on the run last week after allegedly killing a couple and a policeman, and wounding three people. Another officer was killed and one wounded before the cabin in which Dorner was holed up burned in a fire.

Dorner had posted online a chilling manifesto in which he threatened to kill policemen and their families, and blamed the LAPD for treating him unfairly in his sacking in 2008.

The manhunt came to a climax Tuesday in a cabin near a snow-covered ski resort, after Dorner was spotted in a stolen vehicle and then fled on foot after crashing one vehicle and carjacking another.

San Bernardino County Sheriff John McMahon said that there was a prolonged firefight with the 33-year-old, who barricaded himself in the cabin after a six-day manhunt.

When they had exhausted other means, SWAT officers used a tractor-type device to open up the windows and walls of the cabin, and inserted a pyrotechnic chemical, to try to force Dorner to surrender.

A blaze erupted, starting at one corner of the cabin. As the flames took hold, after a period of no firing, "We heard a distinct single gunshot coming from inside the house," said McMahon.

The sound of it "indicated to me (that) a different kind of weapon had been fired," he added.

- AFP/ck

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Vintage steam engine back on Shimla-Kalka heritage track

SHIMLA: The British era steam engine, KC-520, chugged on the Shimla-Kalka heritage track on Friday, after a gap of four years. The only narrow gauge steam engine, which dates back to 1903, KC-520 towed four chartered coaches, carrying around 25 passengers, mainly foreigners, successfully between Shimla and Kathlighat.

Railway officials at the Shimla railway station cordoned off the track when the engine set off on its journey around 11.40am. A member of the group from UK travelling in one of the coaches, Viam, told TOI, "It is wonderful to travel in the steam engine. It is certainly a momentous journey and weaving a magnificent image of steam spewing up while traversing through the verdant vales."

Sources said the steam engine was plying following a chartered booking by the UK group. The engine was sent to Amritsar in 2008 for repair works and brought back to Shimla on November 20. It ran a successful trial run on December 5, 2012. Information procured from the Baba Bhalku rail museum in Shimla reveals that the steam engine has been declared a heritage property by UNESCO and that it is the only one being run on the Kalka-Shimla narrow gauge. Technically, the engine's specialty is that it runs on a gradient of 1 in 33 around 3%, which is quite steep and a very difficult gradient compared to other hill tracks like that of Darjeeling.

This steam engine has been quite a hit with tourists, especially foreigners. This particular engine was run for the first time in 1905 and as compared to the diesel locos it requires repeated refilling of water. Before December 2012 it was last run on trial basis in November 2008 from Summer Hill to Shimla and thereafter taken to Amritsar. This engine was brought out of retirement from Saharanpur.

As per records, the KC-520 engine is said to be built by North British Locomotive Company for Rs 30,000 and was put out of service in 1971 after the advent of diesel locomotives. The KC-520 was again put into use in 2001 for small trips between Shimla and Kathlighat for foreign tourists, as well as high end tourists, besides persons of corporate sector and at a cost of around Rs 1.08 lakh for a short trip for 25 people, it became a popular attraction.

Aaron Kelly, a British tourist who travelled on the train, said: "The journey on this narrow-gauge rail line is always exhilarating, especially when a steam locomotive is used to draw the coaches."

Another tourist, Daniel Hall said travelling on a wheeled vehicle consisting of a coal-propelled engine "reminds me of the Raj heritage".

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States' choices set up national health experiment

WASHINGTON (AP) — President Barack Obama's health care overhaul is unfolding as a national experiment with American consumers as the guinea pigs: Who will do a better job getting uninsured people covered, the states or the feds?

The nation is about evenly split between states that decided by Friday's deadline they want a say in running new insurance markets and states that are defaulting to federal control because they don't want to participate in "Obamacare." That choice was left to state governments under the law: Establish the market or Washington will.

With some exceptions, states led by Democrats opted to set up their own markets, called exchanges, and Republican-led states declined.

Only months from the official launch, exchanges are supposed to make the mind-boggling task of buying health insurance more like shopping on Amazon.com or Travelocity. Millions of people who don't have employer coverage will flock to the new markets. Middle-class consumers will be able to buy private insurance, with government help to pay the premiums in most cases. Low-income people will be steered to safety net programs like Medicaid.

"It's an experiment between the feds and the states, and among the states themselves," said Robert Krughoff, president of Consumers' Checkbook, a nonprofit ratings group that has devised an online tool used by many federal workers to pick their health plans. Krughoff is skeptical that either the feds or the states have solved the technological challenge of making the purchase of health insurance as easy as selecting a travel-and-hotel package.

Whether or not the bugs get worked out, consumers will be able to start signing up Oct. 1 for coverage that takes effect Jan. 1. That's also when two other major provisions of the law kick in: the mandate that almost all Americans carry health insurance, and the rule that says insurers can no longer turn away people in poor health.

Barring last-minute switches that may not be revealed until next week, 23 states plus Washington, D.C., have opted to run their own markets or partner with the Obama administration to do so.

Twenty-six states are defaulting to the feds. But in several of those, Republican governors are trying to carve out some kind of role by negotiating with federal Health and Human Services Secretary Kathleen Sebelius. Utah's status is unclear. It received initial federal approval to run its own market, but appears to be reconsidering.

"It's healthy for the states to have various choices," said Ben Nelson, CEO of the National Association of Insurance Commissioners. "And there's no barrier to taking somebody else's ideas and making them work in your situation." A former U.S. senator from Nebraska, Nelson was one of several conservative Democrats who provided crucial votes to pass the overhaul.

States setting up their own exchanges are already taking different paths. Some will operate their markets much like major employers run their health plans, as "active purchasers" offering a limited choice of insurance carriers to drive better bargains. Others will open their markets to all insurers that meet basic standards, and let consumers decide.

Obama's Affordable Care Act remains politically divisive, but state insurance exchanges enjoy broad public support. Setting up a new market was central to former Republican presidential candidate Mitt Romney's health care overhaul as governor of Massachusetts. There, it's known as the Health Connector.

A recent AP poll found that Americans prefer to have states run the new markets by 63 percent to 32 percent. Among conservatives the margin was nearly 4-1 in favor of state control. But with some exceptions, including Idaho, Nevada and New Mexico, Republican-led states are maintaining a hands-off posture, meaning the federal government will step in.

"There is a sense of irony that it's the more conservative states" yielding to federal control, said Sandy Praeger, the Republican insurance commissioner in Kansas, a state declining to run its own exchange. First, she said, the law's opponents "put their money on the Supreme Court, then on the election. Now that it's a reality, we may see some movement."

They're not budging in Austin. "Texas is not interested in being a subcontractor to Obamacare," said Lucy Nashed, spokeswoman for Gov. Rick Perry, who remains opposed to mandates in the law.

In Kansas, Praeger supported a state-run exchange, but lost the political struggle to Gov. Sam Brownback. She says Kansans will be closely watching what happens in neighboring Colorado, where the state will run the market. She doubts that consumers in her state would relish dealing with a call center on the other side of the country. The federal exchange may have some local window-dressing but it's expected to function as a national program.

Christine Ferguson, director of the Rhode Island Health Benefits Exchange, says she expects to see a big shift to state control in the next few years. "Many of the states have just run out of time for a variety of reasons," said Ferguson. "I'd be surprised if in the longer run every state didn't want to have its own approach."

In some ways, the federal government has a head start on the states. It already operates the Medicare Plan Finder for health insurance and prescription plans that serve seniors, and the Federal Employees Health Benefits Program. Both have many of the features of the new insurance markets.

Administration officials are keeping mum about what the new federal exchange will look like, except that it will open on time and people in all 50 states will have the coverage they're entitled to by law.

Joel Ario, who oversaw planning for the health exchanges in the Obama administration, says "there's a rich dialogue going on" as to what the online shopping experience should look like. "To create a website like Amazon is a very complicated exercise," said Ario, now a consultant with Manatt Health Solutions.

He thinks consumers should be able to get one dollar figure for each plan that totals up all their expected costs for the year, including premiums, deductibles and copayments. Otherwise, scrolling through pages of insurance jargon online will be a sure turn-off.

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Dorner Confirmed Dead in Autopsy on Cabin Remains

Christopher Dorner, the ex-Los Angeles police officer who declared himself on a killing spree against his former law enforcement colleagues, is dead.

Authorities this evening confirmed that remains found after a fiery standoff at a California mountain cabin Tuesday were, in fact, Dorner's.

"The charred human remains located in the burned out cabin in Seven Oaks have been positively identified to be that of Christopher Dorner," the San Bernardino County Sheriff-Coroner's Office said in a written statement. "During the autopsy, positive identification was made through dental examination."

FULL COVERAGE: Christopher Dorner Manhunt

PHOTOS: Former LAPD Officer Suspected in Shootings

In a 6,000-word "manifesto," Dorner outlined his anger at the Los Angeles Police Department for firing him, and made threats against individuals he believed were responsible for ending his career with the police force five years ago. Dorner was fired after filing what the LAPD determined to be a false report accusing other cops of brutality.

Dorner is suspected of killing four people, including Monica Quan and her fiance, who were found shot to death Feb. 3. Quan was the daughter of former LAPD Capt. Randal Quan, who was mentioned as a target of Dorner's fury in the manifesto.

Christopher Dorner Hostages: 'He Just Wanted to Clear His Name' Watch Video

Christopher Dorner Believed Dead After Shootout With Police Watch Video

Christopher Dorner Believed Dead After Shootout with Police Watch Video

Dorner is also suspected in the shooting death of Riverside, Calif., Police Officer Michael Crain, whose funeral was Wednesday.

San Bernardino Sheriff's Deputy Jeremiah MacKay, 35, a 15-year veteran and the father of two children, was killed in Tuesday's shootout at the cabin.

A second San Bernardino County sheriff's officer had to undergo multiple surgeries after he was wounded in the cabin shootout, and other officers also were wounded in earlier alleged encounters with Dorner.

After Crain's death, police tracked Dorner to the Big Bear Lake area of Southern California, where his burning truck was found in the mountains late last week.

A couple with a cabin in the area were some of the last people to see Dorner before his final encounter with police. Their 911 call to police triggered a chase that concluded with the fiery standoff at the nearby cabin.

The couple, Karen and Jim Reynolds, said at a news conference Wednesday that their ordeal lasted a few minutes but seemed like hours.

The Reynolds believe Dorner, 33, was holed up starting Friday in their unoccupied cabin in Big Bear, Calif., only steps from where police had set up a command center.

"He said four or five times that he didn't have a problem with us, he just wanted to clear his name," Jim Reynolds said. "He said, 'I don't have a problem with you, so I'm not going to hurt you.'"

Dorner tied their arms and put pillowcases over their heads before fleeing in their purple Nissan, the couple said.

Before he fled, the couple said Dorner told them that he had been watching them before he took over their cabin. Dorner told the couple he could tell they were "hard working, good people."

"He had been watching us and saw me shoveling the snow Friday," Jim Reynolds said.

They say they may have left the cabin door unlocked and that could have been the reason Dorner was able to enter undetected.

Dorner remained "calm and meticulous" throughout the harrowing ordeal, the couple said.

The Reynolds walked into their cabin around noon Tuesday when they came face-to-face with Dorner. There was no question in their minds who he was -- the suspected cop killer at the center of one of the largest manhunts in recent memory.

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Key U.S. general backs keeping Afghan forces at peak strength

WASHINGTON (Reuters) - The U.S. general nominated to oversee a vast region that includes Afghanistan on Thursday backed keeping Afghan forces at a peak strength of 352,000, contrary to current plans to shrink them after NATO declares the war over next year.

General Lloyd Austin, nominated to lead the U.S. military's Central Command, said at his Senate confirmation hearing that a more robust Afghan force, while more costly, would "hedge against any Taliban mischief" following America's longest war.

"Keeping the larger-size force would certainly reassure the Afghans, it would also reassure our NATO allies that we remain committed," Austin said.

The comments came two days after President Barack Obama announced in his State of the Union address that 34,000 U.S. troops - roughly half of the current U.S. force in Afghanistan - would be withdrawn by early 2014.

Obama reassured Americans that the costly, unpopular war was coming to an end, but he left unanswered bigger questions about America's exit strategy, including how many U.S. troops would stay in the country beyond 2014 to help train and advise the Afghans and to battle remnants of al Qaeda.

Obama also did not discuss the future size of the Afghan forces, although a White House fact sheet sent out after his address noted they would remain at 352,000 until "at least" early 2015.

Austin warned the Taliban would be waiting to test them.

"You could reasonably expect that an enemy that's been that determined, that agile, will very soon after we transition begin to try to test the Afghan security forces," Austin said.

Under current plans, the United States and its NATO allies will help build up the Afghan armed forces to 352,000 personnel, a number they are approaching, but the size of the force - which the allies will continue to fund - will be trimmed to 230,000 after 2015.

ECHOES OF IRAQ

The hearing frequently moved away from questions about the Afghan war and other current events to questions about Austin's past role as commander in Iraq, when a failure to strike an immunity deal for U.S. troops led to their total withdrawal in 2011.

Obama administration officials have warned that failure to strike an immunity deal with Afghanistan would also result in a pullout, but Afghan President Hamid Karzai and U.S. officials have expressed confidence a deal can be reached.

Republicans, who have criticized Obama's drawdown strategy in Afghanistan, noted that the president would have left a much smaller force in Iraq than Austin recommended, even if a deal had been struck.

Senator John McCain of Arizona lamented the lack of a U.S. presence in Iraq.

Pressed by Republicans, Austin acknowledged that the situation in Iraq was trending in a "problematic" direction, and agreed that a continued U.S. role would have helped bolster Iraqi forces.

When it came to Afghanistan, Senator Lindsay Graham of South Carolina warned Austin that if Obama sought an insufficient force for the post-2014 mission, he would refuse to vote for funding the war effort.

"It can be as low as 9 or 10,000, that I will stand with them," Graham said.

"If they overrule the commanders and create a force that cannot in my view be successful, I cannot in good conscience vote to continue this operation."

Graham said he would vote for Austin's confirmation once Austin spoke with the former commander of the Afghan mission, General John Allen, about his recommendations to Obama and reported back to the committee about his opinion.

(Reporting by Phil Stewart; Editing by David Brunnstrom)

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COE second open bidding exercise 18 February

SINGAPORE: February's Certificates of Entitlement (COEs) second open bidding exercise opens on Monday at noon.

The tender closes on Wednesday at 4pm.

The total quota available for this tender exercise is 1,608.

Non-transferable categories:

Category A : Cars (1,600cc and below) - 333

Category B : Cars (1,601cc and above) - 303

Category D : Motorcycles 506

Transferable categories:

Category C : Goods Vehicles and Buses - 225

Category E : Open Category - 241

- CNA/ck

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They should answer if they can run a government, says Bengal governor

KOLKATA: Under pressure from an angry police force and a stung city, chief minister Mamata Banerjee on Thursday reacted in haste and shunted police commissioner R K Pachnanda, making him the scapegoat for the political bungling over sub-inspector Tapas Chowdhury's death.

Surajit Kar Purakayastha was named the new police chief.

Pachnanda's removal triggered a stinging reaction from governor M K Narayanan, who said if the top cop's transfer had something to do with what happened in the last few days, "clearly, there is something that is wrong and we will have to look into it".

Asked if he would intervene, the governor said: "That you leave to me. We are a democracy, we have a government that was elected with a massive mandate. I presume they should answer whether they are capable of running a government or not. The governor cannot answer that, he can only act."

The abrupt transfer triggered severe resentment among police officers as well. Although it was Firhad Hakim - a powerful minister in Mamata's cabinet - who prevented the police from taking action in the case, Pachnanda was made the fall guy to save the image of the government, and Mamata herself.

In fact, it was Narayanan's tough talking earlier in the day that had forced Mamata to act. During a visit to the slain officer's residence in Thakurpukur, Narayanan said, "Law and order in the state needs to be restored immediately... No one has any business shielding the accused. Those named in the FIR should be arrested." It was a clear hint at Hakim's clean chit to aide Md Iqbal, whose bodyguard Suvan is suspected to be the shooter. Hakim had publicly said on Wednesday there was no need for further arrests. Narayanan minced no words. "Whoever has said so should not have made the remark," he said.

Hakim has got away clean - so far - in spite of accompanying Iqbal to the trouble spot just after the cop's murder. He had blatantly tried to pass the blame on Congress and even briefed the CM that way. Hakim was so brazen that leader of the opposition Surjya Kanta Mishra remarked that "the urban development minister is behaving like the home minister and the home minister (Mamata) acting like the tourism minister". Mamata was in Tekkhali the day of the murder and spent the next day in Digha.

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Study: Fish in drug-tainted water suffer reaction

BOSTON (AP) — What happens to fish that swim in waters tainted by traces of drugs that people take? When it's an anti-anxiety drug, they become hyper, anti-social and aggressive, a study found. They even get the munchies.

It may sound funny, but it could threaten the fish population and upset the delicate dynamics of the marine environment, scientists say.

The findings, published online Thursday in the journal Science, add to the mounting evidence that minuscule amounts of medicines in rivers and streams can alter the biology and behavior of fish and other marine animals.

"I think people are starting to understand that pharmaceuticals are environmental contaminants," said Dana Kolpin, a researcher for the U.S. Geological Survey who is familiar with the study.

Calling their results alarming, the Swedish researchers who did the study suspect the little drugged fish could become easier targets for bigger fish because they are more likely to venture alone into unfamiliar places.

"We know that in a predator-prey relation, increased boldness and activity combined with decreased sociality ... means you're going to be somebody's lunch quite soon," said Gregory Moller, a toxicologist at the University of Idaho and Washington State University. "It removes the natural balance."

Researchers around the world have been taking a close look at the effects of pharmaceuticals in extremely low concentrations, measured in parts per billion. Such drugs have turned up in waterways in Europe, the U.S. and elsewhere over the past decade.

They come mostly from humans and farm animals; the drugs pass through their bodies in unmetabolized form. These drug traces are then piped to water treatment plants, which are not designed to remove them from the cleaned water that flows back into streams and rivers.

The Associated Press first reported in 2008 that the drinking water of at least 51 million Americans carries low concentrations of many common drugs. The findings were based on questionnaires sent to water utilities, which reported the presence of antibiotics, sedatives, sex hormones and other drugs.

The news reports led to congressional hearings and legislation, more water testing and more public disclosure. To this day, though, there are no mandatory U.S. limits on pharmaceuticals in waterways.

The research team at Sweden's Umea University used minute concentrations of 2 parts per billion of the anti-anxiety drug oxazepam, similar to concentrations found in real waters. The drug belongs to a widely used class of medicines known as benzodiazepines that includes Valium and Librium.

The team put young wild European perch into an aquarium, exposed them to these highly diluted drugs and then carefully measured feeding, schooling, movement and hiding behavior. They found that drug-exposed fish moved more, fed more aggressively, hid less and tended to school less than unexposed fish. On average, the drugged fish were more than twice as active as the others, researcher Micael Jonsson said. The effects were more pronounced at higher drug concentrations.

"Our first thought is, this is like a person diagnosed with ADHD," said Jonsson, referring to attention deficit-hyperactivity disorder. "They become asocial and more active than they should be."

Tomas Brodin, another member of the research team, called the drug's environmental impact a global problem. "We find these concentrations or close to them all over the world, and it's quite possible or even probable that these behavioral effects are taking place as we speak," he said Thursday in Boston at the annual meeting of the American Association for the Advancement of Science.

Most previous research on trace drugs and marine life has focused on biological changes, such as male fish that take on female characteristics. However, a 2009 study found that tiny concentrations of antidepressants made fathead minnows more vulnerable to predators.

It is not clear exactly how long-term drug exposure, beyond the seven days in this study, would affect real fish in real rivers and streams. The Swedish researchers argue that the drug-induced changes could jeopardize populations of this sport and commercial fish, which lives in both fresh and brackish water.

Water toxins specialist Anne McElroy of Stony Brook University in New York agreed: "These lower chronic exposures that may alter things like animals' mating behavior or its ability to catch food or its ability to avoid being eaten — over time, that could really affect a population."

Another possibility, the researchers said, is that more aggressive feeding by the perch on zooplankton could reduce the numbers of these tiny creatures. Since zooplankton feed on algae, a drop in their numbers could allow algae to grow unchecked. That, in turn, could choke other marine life.

The Swedish team said it is highly unlikely people would be harmed by eating such drug-exposed fish. Jonsson said a person would have to eat 4 tons of perch to consume the equivalent of a single pill.

Researchers said more work is needed to develop better ways of removing drugs from water at treatment plants. They also said unused drugs should be brought to take-back programs where they exist, instead of being flushed down the toilet. And they called on pharmaceutical companies to work on "greener" drugs that degrade more easily.

Sandoz, one of three companies approved to sell oxazepam in the U.S., "shares society's desire to protect the environment and takes steps to minimize the environmental impact of its products over their life cycle," spokeswoman Julie Masow said in an emailed statement. She provided no details.

___

Online:

Overview of the drug: http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682050.html

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