Huge study: 5 mental disorders share genetic links


WASHINGTON (AP) — The largest genetic study of mental illnesses to date finds five major disorders may not look much alike but they share some gene-based risks. The surprising discovery comes in the quest to unravel what causes psychiatric disorders and how to better diagnose and treat them.


The disorders — autism, attention deficit-hyperactivity disorder or ADHD, bipolar disorder, major depressive disorder and schizophrenia — are considered distinct problems. But findings published online Wednesday suggest they're related in some way.


"These disorders that we thought of as quite different may not have such sharp boundaries," said Dr. Jordan Smoller of Massachusetts General Hospital, one of the lead researchers for the international study appearing in The Lancet.


That has implications for learning how to diagnose mental illnesses with the same precision that physical illnesses are diagnosed, said Dr. Bruce Cuthbert of the National Institute on Mental Health, which funded the research.


Consider: Just because someone has chest pain doesn't mean it's a heart attack; doctors have a variety of tests to find out. But there's no blood test for schizophrenia or other mental illnesses. Instead, doctors rely on symptoms agreed upon by experts. Learning the genetic underpinnings of mental illnesses is part of one day knowing if someone's symptoms really are schizophrenia and not something a bit different.


"If we really want to diagnose and treat people effectively, we have to get to these more fine-grained understandings of what's actually going wrong biologically," Cuthbert explained.


Added Mass General's Smoller: "We are still in the early stages of understanding what are the causes of mental illnesses, so these are clues."


The Psychiatric Genomics Consortium, a collaboration of researchers in 19 countries, analyzed the genomes of more than 61,000 people, some with one of the five disorders and some without. They found four regions of the genetic code where variation was linked to all five disorders.


Of particular interest are disruptions in two specific genes that regulate the flow of calcium in brain cells, key to how neurons signal each other. That suggests that this change in a basic brain function could be one early pathway that leaves someone vulnerable to developing these disorders, depending on what else goes wrong.


For patients and their families, the research offers no immediate benefit. These disorders are thought to be caused by a complex mix of numerous genes and other risk factors that range from exposures in the womb to the experiences of daily life.


"There may be many paths to each of these illnesses," Smoller cautioned.


But the study offers a lead in the hunt for psychiatric treatments, said NIMH's Cuthbert. Drugs that affect calcium channels in other parts of the body are used for such conditions as high blood pressure, and scientists could explore whether they'd be useful for psychiatric disorders as well.


The findings make sense, as there is some overlap in the symptoms of the different disorders, he said. People with schizophrenia can have some of the same social withdrawal that's so characteristic of autism, for example. Nor is it uncommon for people to be affected by more than one psychiatric disorder.


___


Online:


http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)60223-8/abstract


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Arias Liked Some Kinky Sex, She Admits












Though accused murderer Jodi Arias said she sometimes felt "like a prostitute" at the hands of her ex-boyfriend, Travis Alexander, she admitted today that she often enjoyed their sex life and even suggested sex acts they could try.


Prosecutor Juan Martinez, after a day of aggressive questioning and bickering with Arias, asked her about her own suggestions for her sex life with Alexander, including a phone conversation in which she suggested using sexual lubricant.


Arias, 32, is accused of killing Alexander, but claims it was in self-defense.
Timeline of the Jodi Arias Trial


"You introduced KY Jelly into the relationship to make it more sexually enjoyable, right? When we're talking about the level of experimentation, it looks like both of you were experimenting together sexually. So when we hear things like, 'I felt like a prostitute,' that's not exactly true, is it?" Martinez said.


"It was often mutual," Arias said. "I didn't feel like a prostitute during, just after."








Jodi Arias Admits to Killing Man, Lying to Police Watch Video











Jodi Arias Testimony: Prosecution's Cross-Examination Watch Video





Martinez showed the jury a text message Arias sent offering to perform oral sex on Alexander, comparing it to a statement she made on direct testimony saying that she once felt like a prostitute when Alexander tossed a piece of chocolate at her and walked away without a word after she performed oral sex.


"How is it you can say you 'felt like a prostitute' when you're moving the relationship ahead like this?" Martinez asked. "The act itself is the same thing, and here you're requesting it. The geography is different, but that aside, isn't it the same act? And you're requesting it?"


"When he (ejaculated) and left afterward I felt like a prostitute. When we mutually went through things together I didn't," she said.


Arias also admitted that she sent Alexander a topless photo of herself after he sent her photos of his penis, and that she only did it after she had her breasts enhanced surgically.


Catching Up on the Trial? Check Out ABC News' Jodi Arias Trial Coverage


The testimony came as Martinez continued his efforts to discredit Arias' testimony on the stand, including her statements that she often succumbed to Alexander's sexual fantasies so she wouldn't hurt his feelings. Martinez has focused on portraying Arias as a liar for much of his direct examination.


Arias is charged with murder for killing her ex-boyfriend Travis Alexander at his home in Mesa, Ariz., in June 2008. She claims she killed him in self defense and that he had been increasingly violent and sexually demanding in the months before the confrontation. She also claimed he was interested in young boys.


The prosecution claims she killed him in a jealous rage. She could face the death penalty if convicted of first degree murder.

Jodi Arias Trial See Tempers Flare



Earlier in the day,tempers flared between Arias and prosecutor Martinez as the prosecutor tried to detail Arias' history of spying on her boyfriends, but Arias complained that his aggressive style of questioning made her "brain scramble."


Arias and Martinez, who have sparred throughout two prior days of cross-examination, spent more than 10 minutes bickering over Martinez's word choices and his apparent "anger."


The morning's testimony, and Martinez's points about Arias' alleged spying, were largely interrupted by the spats.


"Are you having trouble understanding me?" Martinez yelled.


"Yes because sometimes cause you go in circles," Arias answered.






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Italy parties seek way out of election stalemate


ROME (Reuters) - Italy's stunned political parties searched for a way forward on Tuesday after an inconclusive election gave none of them a parliamentary majority and threatened prolonged instability and a renewal of the European financial crisis.


The results, notably the dramatic surge of the anti-establishment 5-Star Movement of comic Beppe Grillo, left the center-left bloc with a majority in the lower house but without the numbers to control the upper chamber, the Senate.


Financial markets fell sharply at the prospect of a stalemate that reawakened memories of the crisis that pushed Italy's borrowing costs toward unsustainably high levels and brought the euro zone to the brink of collapse in 2011.


"The winner is: Ingovernability," ran the headline in Rome newspaper Il Messaggero, reflecting the deadlock the country will have to confront in the next few weeks as sworn enemies are forced to work together to form a government.


Ratings agency Standard & Poor's said on Tuesday that policy choices of the next Italian government would be crucial for the country's creditworthiness, underlining the need for a coalition that can agree on new reforms.


Pier Luigi Bersani, head of the center-left Democratic Party (PD), has the difficult task of trying to agree a "grand coalition" with former prime minister Silvio Berlusconi, the man he blames for ruining Italy, or striking a deal with Grillo, a completely unknown quantity in conventional politics.


The alternative is new elections either immediately or within a few months, although both Berlusconi and Bersani have indicated that they want to avoid a return to the polls if possible: "Italy cannot be ungoverned and we have to reflect," Berlusconi said in an interview on his own television station.


For his part, Grillo, whose movement won the most votes of any single party, has indicated that he believes the next government will last no more than six months.


"They won't be able to govern," he told reporters on Tuesday. "Whether I'm there or not, they won't be able govern."


He said he would work with anyone who supported his policy proposals, which range from anti-corruption measures to green-tinted energy measures but rejected suggestions of entering a formal coalition: "It's not time to talk of alliances... the system has already fallen," he said.


The election, a massive rejection of the austerity policies applied by Prime Minister Mario Monti with the backing of international leaders from U.S. President Barack Obama to German Chancellor Angela Merkel, caused consternation across Europe.


German Finance Minister Wolfgang Schaeuble put a brave face on it, saying "that's democracy".


Spanish Foreign Minister Jose Manuel Garcia-Margallo was more pessimistic.


"This is a jump to nowhere that does not bode well either for Italy or Europe," he said.


A long recession and growing disillusionment with mainstream parties and tax-raising austerity fed a bitter public mood and contributed to the massive rejection of Monti, whose centrist coalition was relegated to the sidelines.


Projections by the Italian center for Electoral Studies showed that the center-left will have 121 seats in the Senate, against 117 for the center-right alliance of Berlusconi's PDL and the regionalist Northern League. Grillo would take 54.


That leaves no party with the majority in a chamber which a government must control to pass legislation.


"THE BELL IS RINGING"


On a visit to Germany, President Giorgio Napolitano said he would not comment until the parties had consulted with each other and Bersani called on Berlusconi and Grillo to "assume their responsibilities" to ensure Italy could have a government.


He warned that the election showed austerity policies alone were no answer to the economic crisis and said the result carried implications beyond Italy.


"The bell is ringing for Europe as well," he said in his first public comments since the election.


He said he would present a limited number of reform proposals to parliament, focusing on jobs, institutional reform and European policy.


However forming an alliance may be long and difficult and could test the sometimes fragile internal unity of the mainstream parties.


"The idea of a majority without Grillo is unthinkable. I don't know if anyone in the PD is considering it but I'm against it," said Matteo Orfini, a member of Bersani's PD secretariat.


"The idea of a PD-PDL government, even if it's backed by Monti, doesn't make any sense," he said.


For his part, Berlusconi won a boost when his Northern League ally Roberto Maroni won the election to become regional president of Lombardy, Italy's economic heartland and one of the richest and most productive areas of Europe.


For Italian business, with an illustrious history of export success, the election result brought dismay that there would be no quick change to what they see as a regulatory sclerosis that has kept the economy virtually stagnant for a decade.


"This is probably the worst possible scenario," said Francesco Divella, whose family began selling pasta under its eponymous brand in 1890 in the southern region of Puglia.


Berlusconi's campaign, mixing sweeping tax cut pledges with relentless attacks on Monti and Merkel, echoed many of the themes pushed by Grillo and underlined the increasingly angry mood of the Italian electorate.


But even if the next government turns away from the tax hikes and spending cuts brought in by Monti, it will struggle to revive an economy that has scarcely grown in two decades.


Monti was widely credited with tightening Italy's public finances and restoring its international credibility after the scandal-plagued Berlusconi, who is currently on trial for having sex with an under-age prostitute.


However, Monti struggled to pass the kind of structural reforms needed to improve competitiveness and lay the foundations for a return to economic growth. A weak center-left government may not find it any easier.


The view from some voters, weary of the mainstream parties, was unrepentant: "It's good," said Roger Manica, 28, a security guard in Rome, who voted for the center-left PD.


"Next time I'll vote 5-Star. I like that they are changing things, even if it means uncertainty. Uncertainty doesn't matter to me, for me what's important is a good person who gets things done," he said. "Look how well they've done."


(Additional reporting by Barry Moody, Gavin Jones, Lisa Jucca, Steven Jewkes, Steve Scherer, Catherine Hornby and Massimiliano Di Giorgio, Annika Breidthardt in Berlin. Writing by Philip Pullella and James Mackenzie; Editing by Peter Graff)



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Pope readies for final audience on resignation eve






VATICAN CITY: Pope Benedict XVI will hold the last audience of his pontificate in St Peter's Square on Wednesday on the eve of his historic resignation as leader of the world's 1.2 billion Catholics.

Tens of thousands of pilgrims are expected at the Vatican to bid a final farewell to an 85-year-old pope who abruptly cut short his pontificate by declaring he was too weak in body and mind to keep up with the modern world.

The Vatican says 50,000 people have obtained tickets for the event but many more may come and city authorities are preparing for 200,000, installing metal detectors in the area, deploying snipers and setting up field clinics.

No parking has been allowed in the zone since 10:00 pm Tuesday, and cars were to be barred entirely from 7:00 am on Wednesday.

The weekly audience, which is exceptionally being held in St Peter's Square because of the numbers expected, is to begin at around 10:30 am (0930 GMT) and usually lasts around an hour with a mixture of prayers and religious instruction from the pope.

Benedict will be the first pope to step down since the Middle Ages -- a break with Catholic tradition that has worried conservatives but kindled the hopes of Catholics around the world who want a breath of new life in the Church.

Rome has been gripped by speculation over what prompted Benedict to resign and who the leading candidates might be to replace him.

Rumours and counter-rumours in the Italian media suggest cut-throat behind-the-scenes lobbying, prompting the Vatican to condemn what it has called "unacceptable pressure" to influence the papal election.

Campaign groups have also lobbied the Vatican to exclude two cardinals accused of covering up child sex abuse from the upcoming election conclave.

The Vatican has said Benedict will receive the title of "Roman pontiff emeritus" and can still be addressed as "Your Holiness" and wear the white papal cassock after he officially steps down at 1900 GMT on Thursday.

Just before that time, the Vatican said Benedict will be whisked off by helicopter to the papal summer residence of Castel Gandolfo near Rome where he will begin a life out of the public eye.

Benedict will wave from the residence's balcony one last time before retreating to a private chapel and, as he has said, a life "hidden from the world".

On the hour he formally loses his powers as sovereign pontiff, the liveried Swiss Guard that traditionally protects popes will leave the residence.

The shock of the resignation and its unprecedented nature in the Church's modern history has left the Vatican sometimes struggling to explain the implications and Benedict's future status -- from the banal to the theological.

Some Catholics find it hard to come to terms with the idea that someone who was elected in a supposedly divinely inspired vote could simply resign.

The Vatican has said Benedict will lose his power of divine infallibility -- a sort of supreme authority in doctrinal matters -- as soon as he steps down.

The Vatican has also explained that the personalised gold Fisherman's Ring traditionally used to seal papal documents -- a key symbol of the office -- will be destroyed by a special cardinal, as is customary in Catholic tradition.

Benedict has also chosen to swap his trademark red shoes for a brown pair given to him by artisans in Mexico during a trip last year.

Starting next week, cardinals from around the world will begin a series of meetings to decide what the priorities for the Catholic Church should be, set a start date for the conclave and consider possible candidates for pope.

The conclave -- a centuries-old tradition with an elaborate ritual -- is supposed to be held within 15 to 20 days of the death of the pope, but Benedict has given special dispensation for the cardinals to bring that date forward.

Cardinals have been flying in from around the world including US prelate Roger Mahony, a former archbishop of Los Angeles stripped of all church duties for mishandling and covering up sex abuse claims against dozens of priests.

A total of 115 "cardinal electors" are scheduled to take part after another voter, British cardinal Keith O'Brien said he would not be taking part after allegations emerged that he made unwanted advances towards priests in the 1980s.

- AFP/ck



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Rape victim attempts suicide in courtroom

AHMEDABAD: A rape victim attempted suicide in the courtroom of Gujarat high court on Tuesday by consuming pesticide. She was rushed to the Sola Civil Hospital, where her condition is said to be critical. This is the second such incident since January when a rape victim attempted suicide in a courtroom.

In this case, the 27-year old woman had moved Gujarat HC to appeal against a city sessions court's decision to grant anticipatory bail to the rape accused, Sandeep Panchal. On Tuesday, her lawyer could not attend court due to the demise of his grandmother and Justice Ashish Desai adjourned the hearing.

As soon as the woman heard about the adjournment, she rushed to the courtroom and consumed poison. She was accompanied by her three-year old son. Advocate B M Mangukiya, who was present in the courtroom, took her to the hospital.

He later said that the victim had audio clips in her mobile phone establishing that the accused was threatening that she would meet the same fate as the Delhi gang-rape victim, Nirbhaya. When Sola police later recorded the victim's statement, she handed over this evidence to them.

After the incident, Justice Desai scheduled hearing on the case on Wednesday.

HC's registrar general R P Dholeria said, "She has grievances against police and her family members, not against the court." In her petition at HC the victim has complained about "ill treatment" by city cops.

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C. Everett Koop, 'rock star' surgeon general, dies


NEW YORK (AP) — Dr. C. Everett Koop has long been regarded as the nation's doctor— even though it has been nearly a quarter-century since he was surgeon general.


Koop, who died Monday at his home in Hanover, N.H., at age 96, was by far the best known and most influential person to carry that title. Koop, a 6-foot-1 evangelical Presbyterian with a biblical prophet's beard, donned a public health uniform in the early 1980s and became an enduring, science-based national spokesman on health issues.


He served for eight years during the Reagan administration and was a breed apart from his political bosses. He thundered about the evils of tobacco companies during a multiyear campaign to drive down smoking rates, and he became the government's spokesman on AIDS when it was still considered a "gay disease" by much of the public.


"He really changed the national conversation, and he showed real courage in pursuing the duties of his job," said Chris Collins, a vice president of amfAR, the Foundation for AIDS Research.


Even before that, he had been a leading figure in medicine. He was one of the first U.S. doctors to specialize in pediatric surgery at a time when children with complicated conditions were often simply written off as untreatable. In the 1950s, he drew national headlines for innovative surgeries such as separating conjoined twins.


His medical heroics are well noted, but he may be better remembered for transforming from a pariah in the eyes of the public health community into a remarkable servant who elevated the influence of the surgeon general — if only temporarily.


"He set the bar high for all who followed in his footsteps," said Dr. Richard Carmona, who served as surgeon general a decade later under President George W. Bush.


Koop's religious beliefs grew after the 1968 death of his son David in a mountain-climbing accident, and he became an outspoken opponent of abortion. His activism is what brought him to the attention of the administration of President Ronald Reagan, who decided to nominate him for surgeon general in 1981. Though once a position with real power, surgeon generals had been stripped of most of their responsibilities in the 1960s.


By the time Koop got the job, the position was kind of a glorified health educator.


But Koop ran with it. One of his early steps involved the admiral's uniform that is bestowed to the surgeon general but that Koop's predecessors had worn only on ceremonial occasions. In his first year in the post, Koop stopped wearing his trademark bowties and suit jackets and instead began wearing the uniform, seeing it as a way to raise the visual prestige of the office.


In those military suits, he surprised the officials who had appointed him by setting aside his religious beliefs and feelings about abortion and instead waging a series of science-based public health crusades.


He was arguably most effective on smoking. He issued a series of reports that detailed the dangers of tobacco smoke, and in speeches began calling for a smoke-free society by the year 2000. He didn't get his wish, but smoking rates did drop from 38 percent to 27 percent while he was in office — a huge decline.


Koop led other groundbreaking initiatives, but perhaps none is better remembered than his work on AIDS.


The disease was first identified in 1981, before Koop was officially in office, and it changed U.S. society. It destroyed the body's immune system and led to ghastly death, but initially was identified in gay men, and many people thought of it as something most heterosexuals didn't have to worry about.


U.S. scientists worked hard to identify the virus and work on ways to fight it, but the government's health education and policy efforts moved far more slowly. Reagan for years was silent on the issue. Following mounting criticism, Reagan in 1986 asked Koop to prepare a report on AIDS for the American public.


His report, released later that year, stressed that AIDS was a threat to all Americans and called for wider use of condoms and more comprehensive sex education, as early as the third grade. He went on to speak frankly about AIDS in an HBO special and engineered the mailing of an educational pamphlet on AIDS to more than 100 million U.S. households in 1988.


Koop personally opposed homosexuality and believed sex should be saved for marriage. But he insisted that Americans, especially young people, must not die because they were deprived of explicit information about how HIV was transmitted.


Koop's speeches and empathetic approach made him a hero to a wide swath of America, including public health workers, gay activists and journalists. Some called him a "scientific Bruce Springsteen." AIDS activists chanted "Koop, Koop" at his appearances and booed other officials.


"I was walking down the street with him one time" about five years ago, recalled Dr. George Wohlreich, director of the College of Physicians of Philadelphia, a medical society with which Koop had longstanding ties. "People were yelling out, 'There goes Dr. Koop!' You'd have thought he was a rock star."


Koop angered conservatives by refusing to issue a report requested by the Reagan White House, saying he could not find enough scientific evidence to determine whether abortion has harmful psychological effects on women.


He got static from some staff at the White House for his actions, but Reagan himself never tried to silence Koop. At a congressional hearing in 2007, Koop spoke about political pressure on the surgeon general post. He said Reagan was pressed to fire him every day.


After his death was reported Monday, the tributes poured forth, including a statement from New York Mayor Michael Bloomberg, who has made smoking restrictions a hallmark of his tenure.


"The nation has lost a visionary public health leader today with the passing of former Surgeon General C. Everett Koop, who was born and raised in Brooklyn," Bloomberg said. "Outspoken on the dangers of smoking, his leadership led to stronger warning labels on cigarettes and increased awareness about second-hand smoke, creating an environment that helped millions of Americans to stop smoking — and setting the stage for the dramatic changes in smoking laws that have occurred over the past decade."


Dr. Anthony Fauci of the National Institutes of Health taught Koop what was known about AIDS during quiet after-hours talks in the early 1980s and became a close friend.


"A less strong person would have bent under the pressure," Fauci said. "He was driven by what's the right thing to do."


Carmona, a surgeon general years later, said Koop was a mentor who preached the importance of staying true to the science in speeches and reports — even when it made certain politicians uncomfortable.


"We remember him for the example he set for all of us," Carmona said.


Koop's nomination originally was met with staunch opposition. Women's groups and liberal politicians complained Reagan had selected him only because of his conservative views, especially his staunch opposition to abortion.


Foes noted that Koop traveled the country in 1979 and 1980 giving speeches that predicted a progression "from liberalized abortion to infanticide to passive euthanasia to active euthanasia, indeed to the very beginnings of the political climate that led to Auschwitz, Dachau and Belsen."


But Koop, a devout Presbyterian, was confirmed as surgeon general after he told a Senate panel he would not use the post to promote his religious ideology. He kept his word and eventually won wide respect with his blend of old-fashioned values, pragmatism and empathy.


Koop was modest about his accomplishments, saying before leaving office in 1989, "My only influence was through moral suasion."


The office declined after that. Few of his successors had his speaking ability or stage presence. Fewer still were able to secure the support of key political bosses and overcome the meddling of everyone else. The office gradually lost prestige and visibility, and now has come to a point where most people can't name the current surgeon general. (It's Dr. Regina Benjamin.)


Even after leaving office, Koop continued to promote public health causes, from preventing childhood accidents to better training for doctors.


"I will use the written word, the spoken word and whatever I can in the electronic media to deliver health messages to this country as long as people will listen," he promised.


In 1996, he rapped Republican presidential hopeful Bob Dole for suggesting that tobacco was not invariably addictive, saying Dole's comments "either exposed his abysmal lack of knowledge of nicotine addiction or his blind support of the tobacco industry."


He maintained his personal opposition to abortion. After he left office, he told medical students it violated their Hippocratic oath. In 2009, he wrote to Senate Majority Leader Harry Reid, urging that health care legislation include a provision to ensure doctors and medical students would not be forced to perform abortions. The letter briefly set off a security scare because it was hand delivered.


Koop served as chairman of the National Safe Kids Campaign and as an adviser to President Bill Clinton's health care reform plan.


Worried that medicine had lost old-fashioned caring and personal relationships between doctors and patients, Koop opened an institute at Dartmouth College in New Hampshire to teach medical students basic values and ethics. He also was a part-owner of a short-lived venture, drkoop.com, to provide consumer health care information via the Internet.


Koop was the only son of a Manhattan banker and the nephew of a doctor. He said by age 5 he knew he wanted to be a surgeon and at age 13 he practiced his skills on neighborhood cats. He attended Dartmouth, where he received the nickname Chick, short for "chicken Koop." It stuck for life.


He received his medical degree at Cornell Medical College, choosing pediatric surgery because so few surgeons practiced it. In 1938, he married Elizabeth Flanagan, the daughter of a Connecticut doctor. They had four children. Koop's wife died in 2007, and he married Cora Hogue in 2010.


He was appointed surgeon-in-chief at Children's Hospital in Philadelphia and served as a professor at the University of Pennsylvania School of Medicine. He pioneered surgery on newborns and successfully separated three sets of conjoined twins. He won national acclaim by reconstructing the chest of a baby born with the heart outside the body.


Although raised as a Baptist, he was drawn to a Presbyterian church near the hospital, where he developed an abiding faith. He began praying at the bedside of his young patients — ignoring the snickers of some of his colleagues.


___


Contributing to this report were Associated Press writers Wilson Ring in Montpelier, Vt.; Jeff McMillan in Philadelphia; and AP Medical Writer Lauran Neergaard in Washington.


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Arias Claims Innocence on Death Penalty Charge












Accused murderer Jodi Arias was confronted today with a barrage of lies she told after she killed her ex-boyfriend Travis Alexander, but she twice defiantly declared that she was innocent of first degree murder.


"It's the truth. I'm innocent of that charge," Arias said to prosecutor Juan Martinez, referring to the criminal charge that could carry the threat of the death sentence if she is found guilty.


Arias admitted on the stand that she lied for months and years after killing her ex-boyfriend, telling investigators and friends that she had nothing to do with Alexander's grisly death, in which he was stabbed 27 times, his throat was slashed, and he was shot in the head.


Eventually, Arias confessed to the killing, but claims it was in self-defense.


Today, prosecutors hammered Arias about her lying, getting her to admit to lies she told and playing video of her police interrogation and a TV interview in which she told stories that she has since conceded were not true.



See the Evidence in the Jodi Arias Murder Trial


In an interview with NBC's "48 Hours," Arias said she smiled for her mug shot partly because she knew she was innocent.


"You truly believe that you didn't do anything wrong here?" the prosecutor asked incredulously.








Jodi Arias Testimony: Prosecution's Cross-Examination Watch Video









Jodi Arias Remains Calm Under Cross-Examination Watch Video









Jodi Arias Doesn't Remember Stabbing Ex-Boyfriend Watch Video





"I believed that I knew that I was not guilty of first-degree murder and I did plan to be dead," she replied, a reference to her claim that she planned to commit suicide.


Catching Up on the Trial? Check Out ABC News' Jodi Arias Trial Coverage


During a day of contentious questions and answers between Martinez and Arias, the prosecutor used Arias' own diary entries and text messages to show contradictions of her claims that Alexander was abusive toward her, that he hit her and tried to choke her.


Arias said that in early 2008, Alexander hit her in the neck while they were riding in his car. Martinez showed a diary entry describing the day they rode in the car, and there was no mention of physical violence.


"This entry does not corroborate what you told us happened in the car," he said. "With regard to the (choking incident) you didn't call police. You didn't tell anyone about it. There is no corroboration anywhere in your journal. All we have is your word. Are there photos? Any other writings? Is there a police report? Is there a medical report?"


Arias said there was no evidence that the alleged abuse happened, except for her testimony in court.


"There's no evidence because it didn't happen, did it ma'am?" Martinez yelled.


Arias said that she had told one person about the abuse she claims she suffered at the hands of Alexander, and that it was another ex-boyfriend, Matthew McCartney. But when pressed for details about the conversation in which she told him, Arias became confused and changed her answers.


"I saw (Matt) a few days later, and he called me out on the bruises," Arias testified.


"Where?"


"Over the phone, just days after I think," she said.


"Isn't it true he wouldn't have been able to see your injuries because you were talking over the telephone?"


"No, I was in Yreka (California) by then. I stopped to see Matt after I left Arizona. Let's see, I believe it was two or three days after. I'm not saying there was no telephone call, (but) it was at his house. I went and saw Matt, and some make-up wore off, and he confronted me on (the bruises)."


Martinez said that McCartney has denied the conversation ever took place.






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Motor Racing: Ecclestone wants Melbourne race for '50 years'






SYDNEY: Formula One ringmaster Bernie Ecclestone said Tuesday he would happily sign a contract for Melbourne to host the Grand Prix for 50 years, declaring "everybody loves Australia".

The sport has a contract with Melbourne until 2015 but beyond that it is up in the air, and other cities have expressed interest in snapping up the event which Ecclestone has previously said is the "least viable" on the F1 calendar.

Ecclestone said he hoped to travel to Melbourne for the season-opening 2013 race on March 17, in a year in which negotiations on a new contract are set to begin.

"Everybody loves Australia, loves Australian people and it's good to be there because it's the first race, it's nice, it's relaxed," he said in an official Australian Grand Prix podcast.

"We hope we're going to be in Melbourne forever, although I understand we do get a little bit of criticism and I don't know why.

"We're happy with Melbourne. I'd be happy to sign a 50-year contract. So we don't have a problem with Melbourne."

Ecclestone revealed that other Australian states had contacted him in attempts to poach the event from Victoria, but he indicated he was determined to keep the race in the southern state's capital.

"We get proposals from other parts, but we're happy in Melbourne," he said.

Ahead of the 2012 race Ecclestone floated the idea of a "divorce from our friends in Melbourne" and "walking away from Australia" when the contract expires.

"The race itself, from our point of view, is probably the least viable of all the races we have," he said then.

Ecclestone also said last year he was keen on a night race, which would fit better with European timezones, helping to sell TV rights there.

Such a move would likely be opposed by residents who live around Melbourne's Albert Park circuit, as well as costing the Victorian state government more to stage.

Last year's race cost taxpayers A$56.7 million (US$58.2 million) -- more than the revenue it generates -- with A$30 million of that reportedly going to Ecclestone for the right to host the race.

Ecclestone said the fee was "purely what the race cost" and included bringing six jumbo jets full of freight transportation to Australia.

Melbourne has hosted the Grand Prix since 1996.

- AFP/ck



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94% women feel unsafe travelling alone in India, survey finds

NEW DELHI: The Delhi gang-rape incident has not just bruised the image of the national Capital, but the country as well. A travel survey has found that 94% women feel unsafe traveling alone, while 84% voted for Delhi as the most unsafe metro. The findings come at a time when an increasing number of women admitted that they preferred to travel alone both for work and leisure.

TripAdvisor, a leading travel site, surveyed 500 women to find that 84% women claimed to have travelled alone for leisure, business or both. The respondents were a mix of working women, including a number of self employed, as well as homemakers.

The survey also brings to light the disturbing fact that 94% women worry about their safety — always or at least sometimes — when they travel alone within India. Among women who said they travel alone on work, 37% agreed that they don't mind travelling alone but worry about their safety.

Even more dismal is the fact that more women travelers have a better sense of safety overseas than in India. Around 24% respondents said they worry when they travel within India but not when they travel to international destinations, while only 6% suggested otherwise.

Despite the fear and worry, only 33% women said they carry any item for self defense when travelling to a new or unfamiliar city.

Due to the recent spate of crime against women, Delhi has gained notoriety with 84% women claiming it to be the most unsafe metro in the country. Mumbai came out on top as the city considered safest by 34% women. Ahmedabad and Bangalore were tied at a distant second with 12% each.

Among the states, Delhi NCR again topped the hall of shame with 60% women voting it as the most unsafe. At a distant second is Bihar (18%), followed by Uttar Pradesh (8%). A majority of 27% respondents said they considered Maharashtra to be the safest state, followed by Gujarat (15%) and Karnataka (10%).

According to TripAdvisor country manager Nikhil Ganju, "The rise in women travelling alone on business is understandable fallout of the increase in the number of working women. The real surprise is the significant number of Indian women who are choosing to travel solo on vacation. Another interesting insight that highlights a latent opportunity for the hospitality sector is that 78% respondents said they would prefer to stay in an all women's hotel or on a women exclusive floor in a hotel, when travelling alone."

In a break from tradition, Indian women enjoy traveling alone for leisure. Among women who travel alone, 41% respondents said they actually enjoyed travelling alone for work. In addition, 76% said they enjoy going solo on holidays.

And lack of company is definitely not a complaint. In fact, majority (58%) said their biggest incentive for solo vacations was that they could do all the things they want without having to worry about what someone else wants. Around 34% women indicated they loved travelling alone as it was adventurous and exciting. Another 32% claimed the thrill of managing everything by themselves was a motivator as well.

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Koop, who transformed surgeon general post, dies


With his striking beard and starched uniform, former Surgeon General C. Everett Koop became one of the most recognizable figures of the Reagan era — and one of the most unexpectedly enduring.


His nomination in 1981 met a wall of opposition from women's groups and liberal politicians, who complained President Ronald Reagan selected Koop, a pediatric surgeon and evangelical Christian from Philadelphia, only because of his conservative views, especially his staunch opposition to abortion.


Soon, though, he was a hero to AIDS activists, who chanted "Koop, Koop" at his appearances but booed other officials. And when he left his post in 1989, he left behind a landscape where AIDS was a top research and educational priority, smoking was considered a public health hazard, and access to abortion remained largely intact.


Koop, who turned his once-obscure post into a bully pulpit for seven years during the Reagan and George H.W. Bush administrations and who surprised both ends of the political spectrum by setting aside his conservative personal views on issues such as homosexuality and abortion to keep his focus sharply medical, died Monday at his home in Hanover, N.H. He was 96.


An assistant at Koop's Dartmouth College institute, Susan Wills, confirmed his death but didn't disclose its cause.


Dr. Richard Carmona, who served as surgeon general a decade ago under President George W. Bush, said Koop was a mentor to him and preached the importance of staying true to the science even if it made politicians uncomfortable.


"He set the bar high for all who followed in his footsteps," Carmona said.


Although the surgeon general has no real authority to set government policy, Koop described himself as "the health conscience of the country" and said modestly just before leaving his post that "my only influence was through moral suasion."


A former pipe smoker, Koop carried out a crusade to end smoking in the United States; his goal had been to do so by 2000. He said cigarettes were as addictive as heroin and cocaine. And he shocked his conservative supporters when he endorsed condoms and sex education to stop the spread of AIDS.


Chris Collins, a vice president of amFAR, the Foundation for AIDS Research, said many people don't realize what an important role Koop played in the beginning of the AIDS epidemic.


"At the time, he really changed the national conversation, and he showed real courage in pursuing the duties of his job," Collins said.


Even after leaving office, Koop continued to promote public health causes, from preventing childhood accidents to better training for doctors.


"I will use the written word, the spoken word and whatever I can in the electronic media to deliver health messages to this country as long as people will listen," he promised.


In 1996, he rapped Republican presidential hopeful Bob Dole for suggesting that tobacco was not invariably addictive, saying Dole's comments "either exposed his abysmal lack of knowledge of nicotine addiction or his blind support of the tobacco industry."


Although Koop eventually won wide respect with his blend of old-fashioned values, pragmatism and empathy, his nomination met staunch opposition.


Foes noted that Koop traveled the country in 1979 and 1980 giving speeches that predicted a progression "from liberalized abortion to infanticide to passive euthanasia to active euthanasia, indeed to the very beginnings of the political climate that led to Auschwitz, Dachau and Belsen."


But Koop, a devout Presbyterian, was confirmed after he told a Senate panel he would not use the surgeon general's post to promote his religious ideology. He kept his word.


In 1986, he issued a frank report on AIDS, urging the use of condoms for "safe sex" and advocating sex education as early as third grade.


He also maneuvered around uncooperative Reagan administration officials in 1988 to send an educational AIDS pamphlet to more than 100 million U.S. households, the largest public health mailing ever.


Koop personally opposed homosexuality and believed sex should be saved for marriage. But he insisted that Americans, especially young people, must not die because they were deprived of explicit information about how HIV was transmitted.


Koop further angered conservatives by refusing to issue a report requested by the Reagan White House, saying he could not find enough scientific evidence to determine whether abortion has harmful psychological effects on women.


Koop maintained his personal opposition to abortion, however. After he left office, he told medical students it violated their Hippocratic oath. In 2009, he wrote to Senate Majority Leader Harry Reid, urging that health care legislation include a provision to ensure doctors and medical students would not be forced to perform abortions. The letter briefly set off a security scare because it was hand delivered.


Koop served as chairman of the National Safe Kids Campaign and as an adviser to President Bill Clinton's health care reform plan.


At a congressional hearing in 2007, Koop spoke about political pressure on the surgeon general post. He said Reagan was pressed to fire him every day, but Reagan would not interfere.


Koop, worried that medicine had lost old-fashioned caring and personal relationships between doctors and patients, opened his institute at Dartmouth to teach medical students basic values and ethics. He also was a part-owner of a short-lived venture, drkoop.com, to provide consumer health care information via the Internet.


Koop was born in the New York City borough of Brooklyn, the only son of a Manhattan banker and the nephew of a doctor. He said by age 5 he knew he wanted to be a surgeon and at age 13 he practiced his skills on neighborhood cats.


He attended Dartmouth, where he received the nickname Chick, short for "chicken Koop." It stuck for life.


Koop received his medical degree at Cornell Medical College, choosing pediatric surgery because so few surgeons practiced it.


In 1938, he married Elizabeth Flanagan, the daughter of a Connecticut doctor. They had four children, one of whom died in a mountain climbing accident when he was 20.


Koop was appointed surgeon-in-chief at Children's Hospital in Philadelphia and served as a professor at the University of Pennsylvania School of Medicine.


He pioneered surgery on newborns and successfully separated three sets of conjoined twins. He won national acclaim by reconstructing the chest of a baby born with the heart outside the body.


Although raised as a Baptist, he was drawn to a Presbyterian church near the hospital, where he developed an abiding faith. He began praying at the bedside of his young patients — ignoring the snickers of some of his colleagues.


Koop's wife died in 2007, and he married Cora Hogue in 2010.


He was by far the best-known surgeon general and for decades afterward was still a recognized personality.


"I was walking down the street with him one time" about five years ago, recalled Dr. George Wohlreich, director of the College of Physicians of Philadelphia, a medical society with which Koop had longstanding ties. "People were yelling out, 'There goes Dr. Koop!' You'd have thought he was a rock star."


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Ring reported from Montpelier, Vt. Cass reported from Washington. AP Medical Writers Lauran Neergaard in Washington and Mike Stobbe in New York contributed to this report.


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